文献类型：期刊文献

英文题名：A new Zn(II) coordination polymer: Selective detection of Fe3+ and treatment activity of the exercise induced traumatic osteoarthritis by reducing reactive oxygen species production

作者：Ding, Xuan-Xi[1];Xie, Zhi-Hui[2];Li, Guang-Jie[1];Zhao, Yue-Sheng[1]

第一作者：Ding, Xuan-Xi

通信作者：Ding, XX[1]

机构：[1]Lanzhou Univ, Dept Orthoped, Hosp 1, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Dept Gynecol & Obstet, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Dept Orthoped, Hosp 1, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Dept Orthoped, Hosp 1, Lanzhou 730000, Peoples R China.

年份：2021

卷号：68

期号：8

起止页码：1531

外文期刊名：JOURNAL OF THE CHINESE CHEMICAL SOCIETY

收录：;Scopus(收录号：2-s2.0-85102201496);WOS:【SCI-EXPANDED(收录号:WOS:000626534000001)】；

基金：The research was supported by the Health Industry Scientific Research Management Project of Gansu Health Committee (GSWSKY2019-73).

语种：英文

外文关键词：coordination polymer; Fe3+ detection; traumatic osteoarthritis

摘要：Through utilizing the fluorescent ligand of tris(4-(triazol-1-yl)phenyl)amine, an innovative Zn(II)-based coordination polymer formulated as {[Zn-2(mu-OH2)(TTPA)(DTDN)(2)center dot DMF]center dot H2O}(n) (1, DTDN = 6,6 '-dithiodinicotinate and TTPA = tris(4-(1H-1,2,4-triazol-1-yl)phenyl)amine) has been successfully prepared by using the H2DTDN as the auxiliary ligand under the solvothermal reaction conditions and structurally characterized. According to the results of fluorescence spectrum analysis, complex 1 has high sensitivity and selectivity for Fe3+ ion. It can effectively detect Fe3+, the linear range is from 0 to 1,000 mu M, and the detection limit of Fe3+ is 8.65 nM. Its treatment activity against exercise induced traumatic osteoarthritis was estimated and its detail mechanism was also investigated in meantime. First, the detection assay of reactive oxygen species (ROS) was implemented for the assessment of the ROS levels produced in the articular soft tissue after compound treatment. Besides, the reverse transcription-polymerase chain reaction (RT-PCR) was also conducted and the genes relative expression related with ROS production was measured after compound exposure.