文献类型：期刊文献

中文题名：益气温阳活血方联合西医常规治疗对早期糖尿病肾病微炎症状态及血管内皮功能的影响

英文题名：Effect on microinflammatory state and vascular endothelial function in early diabetic nephropathy treated by Yiqi Wenyang Huoxue Fang combined conventional Western medicine

作者：刘潇[1];孙晓燕[2];高瑞华[3];方玲[3]

第一作者：刘潇

机构：[1]甘肃中医药大学临床医学院,甘肃兰州730000;[2]甘肃中医药大学附属医院内分泌科,甘肃兰州730020;[3]甘肃省第二人民医院内分泌科,甘肃兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2016

卷号：33

期号：6

起止页码：56

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

基金：2011年甘肃省普通中医药科研立项资助项目(GZK-2011-53)

语种：中文

中文关键词：早期糖尿病肾病;益气温阳活血方;微炎症状态;血管内皮功能;临床研究

外文关键词：early diabetic nephropathy;;Yiqi Wenyang Huoxue Fang;;microinflammatory state;;vascular endothelial function;;clinical study

摘要：目的研究益气温阳活血方联合西医常规治疗对早期糖尿病肾病(DN)微炎症状态及血管内皮功能的影响。方法将86例早期DN患者随机分为治疗组42例和对照组44例,对照组采用常规西医治疗,治疗组在对照组治疗方法的基础上联合益气温阳活血方,治疗时间为12周。分别在治疗前及治疗6周、12周时,检测炎症因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、单核细胞趋化蛋白-1(MCP-1)及血管内皮功能内皮依赖性血管舒张功能(FMD)、尿白蛋白排泄率(UAE)等,并进行统计比较。结果组内比较:治疗组治疗6周和12周时IL-6,TNF-α,MCP-1,UAE均显著降低,与治疗前比较,差异均有统计意义(P<0.05或P<0.01);对照组治疗6周时IL-6,TNF-α,MCP-1,UAE均有所降低,但与治疗前比较差异无统计意义(P>0.05),治疗12周时IL-6,TNF-α,MCP-1,UAE均显著降低,与治疗前比较,差异均有统计意义(P<0.05);2组治疗后FMD均有所升高,但与同组治疗前比较差异均无统计意义(P>0.05)。组间比较:治疗6周时,2组以上各项指标比较差异均无统计意义(P>0.05);治疗12周时,2组IL-6,TNF-α,MCP-1,UAE比较差异均有统计意义(P<0.05),FMD比较差异无统计意义(P>0.05)。结论益气温阳活血方联合西医常规治疗能够抑制早期DN患者血浆炎症因子TNF-α,IL-1,MCP-1的表达,改善体内微炎症状态;能够降低DN患者的UAE,减少对血管内皮功能的损伤,从而减轻肾小球硬化,起到保护肾脏、延缓肾脏病进展的作用。
Objective To investigate the effect on microinflammatory state and vascular endothelial function in early diabetic nephropathy( DN) treated by Yiqi Wenyang Huoxue Fang combined conventional Western medicine.Methods 90 DN cases were randomly divided into treatment group( 42 cases) and control group( 44 cases). The control group was given conventional Western medicine treatment. Based on that,the treatment group was intervened with Yiqi Wenyang Huoxue Fang,12 weeks as a course. Inflammatory factors( IL-6,MCP-1,TNF-α) and FMD,UAE were analyzed statistically on before treatment and the 6thand the 12 thweek after treatment. Results1Intra-group comparison: on the 6thand the 12 thweek,the levels of IL-6,MCP-1,TNF-α,UAE in treatment group decreased more than before,the differences were significant( P < 0. 05 or P < 0. 01); on the 6thweek,the levels of IL-6,MCP-1,TNF-α,UAE in control group also decreased,but compared with before,the differences were not significant( P > 0. 05); on the 12 thweek,all levels decreased notably,the differences were significant( P < 0. 05).Levels of FMD in two groups increased,but compared before,there were no statistical significance( P > 0. 05). 2Inter-group comparison: on the 6thweek,differences of all markers between two groups had no any significance( P> 0. 05); while on the 12 thweek,the differences were significant( P < 0. 05). As to FMD,there was no significance( P > 0. 05). Conclusion The combined therapy can inhibit the expression of TNF-α,IL-1,MCP-1 as well as improve the microinflammatory state. It reduces the level of UAE and lessens the injury on vascular endothelial function,relieves glomerulosclerosis. The therapy plays an important role in protecting kidney and slowing the process of kidney diseases.