文献类型：期刊文献

英文题名：Bibliometric analysis of the research hotspots and trends of circular RNAs

作者：Tuerdi, Reyila[1];Zhang, Hui[2];Wang, Wenxin[1];Shen, Minghui[3];Wei, Xingmin[1]

第一作者：Tuerdi, Reyila

通信作者：Wei, XM[1];Shen, MH[2]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Ctr Dis Prevent & Control, Pathogen Biol Lab, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ Second Hosp, Ctr Lab Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ Second Hosp, Ctr Lab Med, Lanzhou 730000, Gansu, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2024

卷号：10

期号：10

外文期刊名：HELIYON

收录：;Scopus(收录号：2-s2.0-85193431548);WOS:【SCI-EXPANDED(收录号:WOS:001298501000001)】；

基金：Supported by Natural Science Foundation of Gansu Province (No. 21JR1RA173); Lanzhou Science and Technology Planing Project (No. 2020-ZD-90); The Second Hospital of Lanzhou University's Cuiying Science and Technology Innovation' Project (No. CY2020-BJ08) and Education Technology Innovation Research Project (No. 2022B-122).

语种：英文

外文关键词：circRNA; Bibliometric analysis; Visualization; CiteSpace; VOSviewer

摘要：Background and objective: Circular RNAs (circRNAs) have garnered considerable attention in the study of various human diseases due to their ubiquitous expression and potential biological functions. This study conducts a bibliometric and visualization-based analysis of circRNA-related research in diseases, aiming to reveal the current status, hotspots and emerging trends within the field. Methods: Literature published between 2013 and 2022 and indexed in the Web of Science core databases was retrieved. Visualizations of publication volume, countries, authors, institutions, journals, references, and keywords were performed. Microsoft Excel (2021) was used to analyze and graph publication volume and growth trends. Additionally, CiteSpace (version 6.1.R6) and VOSviewer (version 1.6.18) were employed to visualize the bibliographic information. Results: Between 2013 and 2022, a total of 4195 relevant articles on circRNA in the context of diseases were identified. These articles covered 56 countries, 2528 institutions, 19,842 authors and 698 journals, citing 85,541 references. The annual publication volume showed an exponential growth trend, with rapid development post-2017. China, the United States and Germany emerged as the top three contributors, demonstrating high publication volume and total citations. Notably, Nanjing Medical University exhibited the highest publication volume, boasting 291 articles. Burton B. Yang and Li Yang consistently ranked among the top 10 authors in terms of publication volume and citations, emerging as core contributors in this research field. The journal Bioengineered ranked first in terms of published articles (160), with an impact factor of 6.832, while Molecular Cancer garnered the highest impact factor (41.4), solidifying its position as a top journal in this field. Furthermore, high-frequency keywords included "expression" "proliferation" "biomarker" "micro- RNA" "cancer", signifying the prevailing research hotspots and principal themes of this field over the past decade. As of 2022, "biomarker", "prostate cancer","drug resistance","papillary thyroid carcinoma", etc. continued as keywords during the outbreak period. At present, the value of circRNA application is mainly reflected in the two aspects of biomarkers and therapeutic targets, and the prediction of accurate diagnosis and precise treatment based on big data analysis, especially in cancer, will become a hot spot of research in the future. Conclusion: The trajectory of circRNA research from its biological origins to its applications in diseases has been delineated from 2013 to 2022. However, the transition to disease-specific applications and exploration of biological functions warrants further attention in future research endeavors.