文献类型：期刊文献

英文题名：Association between CBS gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region and coronary artery disease: a meta-analysis

作者：Zhu, Zijiang[1,5];Geng, Yuhan[2];Ma, Long[1,3];Yao, Keying[4];Chang, Ruitong[1];Ma, Yongming[1,3];Li, Jialong[1]

第一作者：Zhu, Zijiang

通信作者：Zhu, ZJ[1]

机构：[1]Gansu Prov Matern & Child care Hosp, Gansu Prov Cent Hosp, Dept thorac Surg, Lanzhou, Peoples R China;[2]Ningxia Med Univ, Sch Clin Med, Yinchuan, Peoples R China;[3]Gansu Univ Chinese Med, Dept thorac Surg, Lanzhou, Peoples R China;[4]Lanzhou Univ, Sch Clin Med 2, Lanzhou, Peoples R China;[5]Gansu Prov Matern & Child Care Hosp, Gansu Prov Cent Hosp, Dept Thorac Surg, 999 Mogao Ave,Anning Dist, Lanzhou 730000, Peoples R China

第一机构：Gansu Prov Matern & Child care Hosp, Gansu Prov Cent Hosp, Dept thorac Surg, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Matern & Child Care Hosp, Gansu Prov Cent Hosp, Dept Thorac Surg, 999 Mogao Ave,Anning Dist, Lanzhou 730000, Peoples R China.

年份：2024

卷号：46

期号：1

外文期刊名：CLINICAL AND EXPERIMENTAL HYPERTENSION

收录：;Scopus(收录号：2-s2.0-85187970597);WOS:【SCI-EXPANDED(收录号:WOS:001185635700001)】；

基金：This work was supported by a grant from the Natural Science Foundation of Gansu Province (1606RJZA168).

语种：英文

外文关键词：Cystathionine beta-synthase; polymorphism; coronary artery disease; meta-analysis

摘要：Background Several studies indicate that the cystathionine beta-synthase (CBS) gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region may be correlated with coronary artery disease (CAD) susceptibility, but the results have been inconsistent and inconclusive. Thus, a meta-analysis was conducted to provide a comprehensive estimate of these associations. Methods On the basis of searches in the PubMed, EMBASE, Cochrane Library, Wanfang, VIP, and CNKI databases, we selected 14 case - control studies including 2123 cases and 2368 controls for this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated accordingly using a fixed-effect or random-effect model. Results The results indicated an increased risk between the CBS T833C gene polymorphisms and susceptibility to CAD under the dominant model (CC+CT vs. TT: OR = 1.92, 95% CI: 1.11 similar to 3.32), recessive model (CC vs. CT+TT: OR = 1.88, 95% CI: 1.17 similar to 3.03), and homozygous model (CC vs. TT: OR = 2.46, 95% CI: 1.04 similar to 5.83). In these three genetic models, no significant association was identified for CBS G919A (AA+AG vs. GG: OR = 1.48, 95% CI: 0.45 similar to 4.82),(AA vs. AG+GG: OR = 1.58, 95% CI: 0.93 similar to 2.70),(AA vs. GG: OR = 1.66, 95% CI: 0.40 similar to 6.92) or CBS 844ins68 (II+ID vs. DD: OR = 1.04, 95% CI: 0.80 similar to 1.35),(II vs. ID+DD: OR = 1.09, 95% CI: 0.51 similar to 2.36),(II vs. DD: OR = 1.10, 95% CI: 0.51 similar to 2.39). Conclusions This meta-analysis suggests that the CBS T833C gene polymorphism is significantly associated with the risk of CAD and it shows a stronger association in Asian populations. Individuals with the C allele of the CBS gene T833C polymorphism might be particularly susceptible to CAD.