文献类型：期刊文献

英文题名：Astragaloside IV is a potential natural neuroprotective agent for stroke: a review

作者：Zhang, Qiao-Li[1,2];Qin, Wen-Xiu[3,4];Li, Xiu-Juan[2];Zhang, Yun-Bo[2];Li, Ming[1];Xu, Jun-Feng[3,4];Mao, Zhong-Nan[2]

第一作者：Zhang, Qiao-Li

通信作者：Mao, ZN[1]

机构：[1]Gansu Univ Chinese Med, Dept Rehabil, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Coll Acupuncture & Massage, Lanzhou, Gansu, Peoples R China;[3]Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Dept Acupuncture & Moxibust, Tianjin, Peoples R China;[4]Tianjin Univ Tradit Chinese Med, Acupuncture Dept, Teaching Hosp 1, Tianjin, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Acupuncture & Massage, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：16

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105029293720);WOS:【SCI-EXPANDED(收录号:WOS:001679070000001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the General Project of Joint Scientific Research Fund of Science and Technology Department of Gansu Province (24JRRA884); the Research Project of Traditional Chinese Medicine of Gansu Province (GZKG-2024-84); the Natural Science Foundation of Gansu Province (24JRRA555).

语种：英文

外文关键词：angiogenesis; apoptosis; Astragaloside IV; neuroprotection; oxidative stress; stroke

摘要：Stroke poses a severe threat to human health, with limited therapeutic options currently available. Astragaloside IV (AS-IV), a primary bioactive metabolite derived from Astragalus membranaceus, exhibits multifaceted pharmacological effects, including anti-inflammatory, anti-fibrotic, and antioxidative properties. This review systematically examines recent advances in AS-IV research for stroke treatment, detailing its sources, physicochemical characteristics, mechanisms of action, and therapeutic efficacy in both in vitro and in vivo models. We critically analyze the potential of AS-IV as an adjunctive therapy for stroke, addressing current research hotspots, challenges, and emerging strategies. Notably, AS-IV synergistically enhances neuroprotection when combined with other plant-derived metabolites. This work provides a theoretical foundation for further development of AS-IV in stroke management. In summary, AS-IV demonstrates significant promise as a natural neuroprotective agent worthy of continued exploration for adjuvant stroke therapy.