文献类型：期刊文献

中文题名：基于灰色-模糊系统的中医治疗特发性肺纤维化用药规律研究

英文题名：Study on Medication Rules of TCM Prescription in Treatment of Idiopathic Pulmonary Fibrosis Based on Gray-Fuzzy System

作者：顾志荣[1];许爱霞[1];陈其章[1];萨日娜[1];杨军彦[1];李芳[2];葛斌[1]

第一作者：顾志荣

机构：[1]甘肃省人民医院;[2]甘肃中医药大学

第一机构：甘肃省人民医院

年份：2018

卷号：25

期号：12

起止页码：92

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2017_2018】；

基金：甘肃省人民医院青年科研项目(16GSSY7-2);国家自然科学基金(81260597);甘肃省中医药管理局科研项目(GZK-2015-45)

语种：中文

中文关键词：中医;特发性肺纤维化;灰色关联度;灰色聚类;模糊聚类;用药规律

外文关键词：TCM;idiopathic pulmonary fibrosis;gray correlation;gray clustering;fuzzy clustering;medication rules

摘要：目的探讨灰色-模糊系统数学模型在中医治疗特发性肺纤维化(IPF)组方用药规律研究中的应用,为临床用药及同类型研究提供参考。方法计算机检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)、中文科技期刊数据库(维普网)建库至2017年8月发表于核心期刊的中医治疗IPF相关文献,采用灰色关联度分析、灰色聚类分析及模糊聚类分析等灰色-模糊系统数学模型,挖掘组方规律及用药特点。结果纳入处方191首,涉及药物227味,使用频次>5%的药物有48味,包括黄芪、丹参、当归等;灰色关联度分析及灰色聚类分析均表明,补虚药(黄芪、冬虫夏草、北沙参、党参、白芍等)、化痰止咳平喘药(浙贝母、川贝母、桑白皮、紫菀等)及活血化瘀药(川芎、三七、红花、水蛭等)对中医治疗IPF的方剂评价系统的影响较大;模糊聚类分析得到核心药物组合10组,新处方4首。结论中医治疗IPF用药以补虚、化痰止咳平喘及活血化瘀为主;采用基于灰色-模糊系统的数学模型可较客观、全面地反映其用药特点和规律。
Objective To explore the application of mathematical model based on gray-fuzzy system in the study of TCM in the treatment of idiopathic pulmonary fibrosis （IPF）; To provide references for clinical medication and similar research. Methods Literature published in the core journals about TCM prescription for IPF from the databases of CNKI, CBM, VIP and Wanfang Data was searched from the establishment to August 2017. The gray correlation analysis, gray clustering analysis and fuzzy clustering analysis based on gray-fuzzy system mathematical model were used to dig the rules of prescription and medication characteristics. Results Totally 191 prescriptions were included in the study, involving 227 kinds of Chinese materia medica. 48 kinds of Chinese materia medica showed frequency 〉 5%, including Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma and Angelicae Sinensis Radix, etc. Gray correlation analysis and gray clustering analysis showed that tonifying deficiency medicine （Astragali Radix, Cordyceps, Glehniae Radix, Codonopsis Radix and Paeoniae Radix alba）, resolving phlegm and relieving cough and asthma medicine （Fritillariae Thunbergii Bulbus, Fritillariae Cirrhosae Bulbus, Mori Cortex and Asteris Radix et Rhizoma） and activating blood circulation to dissipate blood stasis medicine （Chuanxiong Rhizoma,Notoginseng Radix et Rhizoma, Carthami Flos and Hirudo） had obvious effects on evaluation system of TCM treatment for IPF prescription. Fuzzy clustering analysis obtained ten core medicine groups and four new prescriptions. Conclusion TCM for the treatment of IPF mainly use medicine with efficacy of tonifying deficiency, relieving cough and asthma and activating blood circulation to dissipate blood stasis. The mathematical model based on gray-fuzzy system can reflect the characteristics and rules of medication objectively and comprehensively.