文献类型：期刊文献

中文题名：胃康漂浮缓释片有效成分的提取工艺研究

英文题名：The research about extraction technology of Weikang Floating Sustained-release Tablet

作者：陈正君[1];景明[1];刘雄[1];刘静[1];赖小东[1]

第一作者：陈正君

机构：[1]甘肃中医学院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2012

卷号：29

期号：2

起止页码：55

中文期刊名：甘肃中医学院学报

外文期刊名：Journal of Gansu College of Traditional Chinese Medicine

基金：兰州市科技发展计划项目(2008-1-181)

语种：中文

中文关键词：胃康漂浮缓释片;有效成分;提取工艺

外文关键词：Weikang Floating Sustained-release Tablet; effective component; extraction process

摘要：目的优选胃康漂浮缓释片有效成分的最佳提取工艺条件。方法以盐酸小檗碱为评价指标,确定提取乙醇浓度;以盐酸小檗碱和干固量为评价指标,对乙醇用量、提取时间、提取次数等影响因素按L9(34)正交实验进行考察,优选胃康漂浮缓释片有效成分的提取工艺条件。结果确定胃康漂浮缓释片有效成分的最佳提取工艺为:6倍量65%乙醇,回流提取3次,每次1 h。结论经中试验证,该工艺条件稳定,有大生产的可行性。
Objective To optimize the best extraction process conditions of the effective component of Weikang Floating Sustained-release Tablet. Methods Determined the concentration of ethanol taking berberine hydrochloride as evaluation indexes;optimized the extraction process conditions of the effective component of Weikang Floa-ting Sustained-release Tablet according to L9（34）orthogonal experiment for an investigation about ethanol dosage,extraction time,extraction times influencing factors taking berberine hydrochloride and dry solid volume as evaluation indexes.Results The best extraction process of Weikang Floating Sustained-release Tablet effective component was determined as 6 times of 65% ethanol,reflux extraction three times,each time 1 h.Conclusion The process conditions were verified stable and possible for industrial production.