文献类型：期刊文献

英文题名：Distinct neural activation patterns in executive functions of schizophrenia patients with predominant positive and negative symptoms: an fNIRS study

作者：Xu, Yinqing[1];Huo, Xiaoning[2];Yang, Xiaolong[2];Ma, Yutai[1];Wang, Yongjie[1,2];Deng, Jibao[1];Zheng, Haozhong[1];Xiu, Meihong[3];Wu, Fengchun[4,5,6]

第一作者：Xu, Yinqing

通信作者：Huo, XN[1];Wu, FC[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Peoples R China;[2]Lanzhou Third Peoples Hosp, Dept Psychol Counseling, 130 Jianlan New Village, Lanzhou 730050, Peoples R China;[3]Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing 100096, Peoples R China;[4]Guangzhou Med Univ, Affiliated Brain Hosp, Dept Psychiat, Guangzhou 510370, Peoples R China;[5]Guangdong Engn Technol Res Ctr Translat Med Mental, Guangzhou 510370, Peoples R China;[6]Guangzhou Med Univ, Key Lab Neurogenet & Channelopathies, Guangdong Prov & Minist Educ China, Guangzhou 510370, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Lanzhou Third Peoples Hosp, Dept Psychol Counseling, 130 Jianlan New Village, Lanzhou 730050, Peoples R China;[2]corresponding author), Guangzhou Med Univ, Affiliated Brain Hosp, Dept Psychiat, Guangzhou 510370, Peoples R China.

年份：2025

卷号：28

期号：9

外文期刊名：INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105014643105);WOS:【SCI-EXPANDED(收录号:WOS:001561120700001)】；

基金：This study was supported by the Lanzhou Science and Technology Program Project (No. 2022-3-56), Lanzhou Health Science and Technology Development Project (2021003), the Lanzhou Science and Technology Program Project (No. 2022-3-55), Key-Area Research and Development Program of Guangdong Province (2023B0303020001), National Natural Science Foundation of China (82301688), Natural Science Foundation of Guangdong (2025A1515010507), Science and Technology Program of Guangzhou (2025A03J3357, 202206060005, 2023A03J0856), Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project (2021B1515020064), Medical Science and Technology Research Foundation of Guangdong (A2023224), Health Science and Technology Program of Guangzhou (20231A010036), Guangzhou Municipal Key Discipline in Medicine (2025-2027), and National Traditional Chinese and Western Medicine Collaborative Project for Major and Complex Diseases (Comprehensive Department of the National Administration of Traditional Chinese Medicine [2024] No. 3), National Integrated Traditional Chinese and Western Medicine "Flagship" Department Construction Project (Comprehensive Department of the National Administration of Traditional Chinese Medicine [2024] No. 221). The funding for this study had no further role in study design, data analysis, or the decision to submit the paper for publication.

语种：英文

外文关键词：schizophrenia; cognitive flexibility; inhibitory control; fNIRS; executive functions

摘要：Objective To investigate the differences in executive functions, specifically cognitive flexibility and inhibitory control, between schizophrenia (SCH) patients with predominantly positive symptoms (PSD) and those with predominantly negative symptoms (NSD), compared to healthy controls, using functional near-infrared spectroscopy (fNIRS).Methods Fifty-two patients with SCH and 29 control subjects were recruited in the study. We employed fNIRS to measure brain activation while participants performed 2 tasks: a cognitive flexibility-switching task and the Stroop task, which assesses inhibitory control. Performance metrics included accuracy and reaction time. The study included 3 groups: SCH patients with PSD, SCH patients with NSD, and healthy controls.Results Patients with SCH exhibited lower accuracy and longer reaction times compared to healthy controls. In terms of brain activation, the PSD group showed the highest levels of prefrontal activation, followed by healthy controls, while the NSD group had the lowest activation levels. Patients had lower accuracy and longer reaction times than healthy controls. The PSD group showed excessive activation in both prefrontal cortex and the dorsolateral prefrontal cortex during both the congruent condition and incongruent condition of the Stroop task. In contrast, the NSD group exhibited higher prefrontal activation under congruent conditions but significantly reduced activation under incongruent conditions.Conclusion Our findings highlight distinct patterns of executive function deficits and brain activation in SCH patients with PSD and NSD. These results suggest that symptom profiles may influence the nature and severity of cognitive impairments and associated neural mechanisms. Future research should further explore these differences to inform targeted interventions and improve clinical outcomes for individuals with SCH. Significance Statement This work analyzes executive function deficits and brain activation patterns in schizophrenia (SCH) patients with predominantly positive symptoms (PSD) and negative symptoms (NSD) using fNIRS. It reveals distinct activation patterns: PSD patients show hyperactivation in the prefrontal cortex, possibly indicating compensatory mechanisms, while NSD patients exhibit reduced activation, especially under conflicting conditions. These findings highlight symptom-specific neural differences in SCH, suggesting that cognitive impairments may vary based on symptom profiles. This research underscores the need for targeted interventions tailored to these unique profiles, laying the groundwork for future studies aimed at improving cognitive outcomes and clinical management in SCH.