文献类型：期刊文献

中文题名：高血压伴抑郁发病机制的研究进展

英文题名：Research advances in pathogenesis of hypertension with comorbid depression

作者：王怡园[1,2];沈路凡[1];王楠[3];马睿玲[1,2];陈小婕[1];田皎[1];寇雨顺[1];张玲娜[1];李嘉玮[1];伊琳[1,2];黄生辉[4];刘雪枫[1]

第一作者：王怡园

机构：[1]甘肃中医药大学中西医结合学院;[2]甘肃省中医药防治慢性疾病重点实验室;[3]兰州大学第一医院全科医学科,甘肃兰州730030;[4]甘肃省中医院神志病科,甘肃兰州730050

第一机构：甘肃中医药大学中西医结合学院

年份：2026

卷号：42

期号：5

起止页码：831

中文期刊名：中国药理学通报

外文期刊名：Chinese Pharmacological Bulletin

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(No 82160842);甘肃省教育厅高校教师创新基金项目(No 2025A-111);甘肃省科技计划青年科技基金项目(No 25JRRA935);甘肃省中医药管理局课题(No GZKP-2023-2)。

语种：中文

中文关键词：高血压;抑郁;共病;发病机制;生物标志物;肾素-血管紧张素系统

外文关键词：hypertension;depression;comorbidity;pathogen?esis;biomarkers;renin-angiotensin system

摘要：高血压患者常伴发抑郁状态,二者共病明显增加心脑血管风险。高血压与抑郁存在复杂双向关联,抑郁可加剧高血压进展,高血压病程亦能诱发情绪障碍。二者共病的发病机制涉及多系统交互作用,包括遗传易感性、肾素-血管紧张素系统(renin-angiotensin system,RAS)过度激活、下丘脑-垂体-肾上腺轴(hypothalamic-pituitary-adrenal axis,HPA)失调、自主神经功能紊乱、免疫炎症反应及肠道菌群代谢异常。基于上述机制,炎症因子、表观遗传调控、血管功能及神经可塑性等特征性生物标志物为早期识别疾病提供了依据。该文系统阐述高血压抑郁共病的机制及潜在生物标志物,以期为精准干预提供新思路。
Patients with hypertension often experience comor?bid depression,and this co-occurrence significantly increases cardiovascular and cerebrovascular risk.A complex bidirec?tional relationship exists between hypertension and depression,where depression can exacerbate the progression of hyperten?sion,and the course of hypertension can also induce mood disor?ders.The pathogenesis of their comorbidity involves multisystem interactions,including genetic susceptibility,overacti?vation of the renin-angiotensin system(RAS),dysregulation of the hypothalamic-pituitary-adrenal(HPA)axis,autonomic ner?vous system dysfunction,immune-inflammatory responses,and intestinal flora/metabolic abnormalities.Based on these mecha?nisms,characteristic biomarkers such as inflammatory factors,epigenetic regulation,vascular function,and neuroplasticity provide a basis for early disease identification.This paper sys?tematically elaborates on the mechanisms and potential biomark?ers of hypertension-depression comorbidity,aiming to offer new insights for its precise intervention.