文献类型：期刊文献

英文题名：Progress of medicinal plants and their active metabolites in ischemia-reperfusion injury of stroke: a novel therapeutic strategy based on regulation of crosstalk between mitophagy and ferroptosis

作者：Zhang, Guozhen[1,2];Wang, Qiang[3];Jiang, Bing[4];Yao, Lihe[3];Wu, Wenjuan[3];Zhang, Xiaoyan[2];Wan, Dongjun[2];Gu, Youquan[1,3]

第一作者：Zhang, Guozhen

通信作者：Gu, YQ[1];Gu, YQ[2]

机构：[1]Lanzhou Univ, Coll Clin Med 1, Lanzhou, Gansu, Peoples R China;[2]Peoples Liberat Army Joint Logist Support Force 94, Dept Neurol, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Univ, Hosp 1, Dept Neurol, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Dept Integrated Chinese & Western Med, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Coll Clin Med 1, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Clin Med 1, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Hosp 1, Dept Neurol, Lanzhou, Gansu, Peoples R China.

年份：2024

卷号：15

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001205911500001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by The Fund of The First Hospital of Lanzhou University (No. ldyyyn2020-108); Natural Science Foundation of Gansu Province (No. 20JR10RA671).

语种：英文

外文关键词：mitophagy; ferroptosis; ischemia-reperfusion injury in stroke; medicinal plants; active metabolites

摘要：The death of cells can occur through various pathways, including apoptosis, necroptosis, mitophagy, pyroptosis, endoplasmic reticulum stress, oxidative stress, ferroptosis, cuproptosis, and disulfide-driven necrosis. Increasing evidence suggests that mitophagy and ferroptosis play crucial regulatory roles in the development of stroke. In recent years, the incidence of stroke has been gradually increasing, posing a significant threat to human health. Hemorrhagic stroke accounts for only 15% of all strokes, while ischemic stroke is the predominant type, representing 85% of all stroke cases. Ischemic stroke refers to a clinical syndrome characterized by local ischemic-hypoxic necrosis of brain tissue due to various cerebrovascular disorders, leading to rapid onset of corresponding neurological deficits. Currently, specific therapeutic approaches targeting the pathophysiological mechanisms of ischemic brain tissue injury mainly include intravenous thrombolysis and endovascular intervention. Despite some clinical efficacy, these approaches inevitably lead to ischemia-reperfusion injury. Therefore, exploration of treatment options for ischemic stroke remains a challenging task. In light of this background, advancements in targeted therapy for cerebrovascular diseases through mitophagy and ferroptosis offer a new direction for the treatment of such diseases. In this review, we summarize the progress of mitophagy and ferroptosis in regulating ischemia-reperfusion injury in stroke and emphasize their potential molecular mechanisms in the pathogenesis. Importantly, we systematically elucidate the role of medicinal plants and their active metabolites in targeting mitophagy and ferroptosis in ischemia-reperfusion injury in stroke, providing new insights and perspectives for the clinical development of therapeutic drugs for these diseases.