文献类型：期刊文献

中文题名：逍遥散防治阿尔茨海默病的作用及配伍机制

英文题名：The effect and compatibility mechanism of Xiaoyao Powder on the Alzheimer's disease

作者：王虎平[1,2];吴红彦[1,2]

第一作者：王虎平

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省中医方药挖掘与创新转化重点实验室甘肃省中药药理与毒理学重点实验室甘肃省中药新产品创制工程实验室

第一机构：甘肃中医药大学

年份：2016

卷号：36

期号：15

起止页码：3632

中文期刊名：中国老年学杂志

外文期刊名：Chinese Journal of Gerontology

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

基金：国家自然科学基金项目(No.81060284);甘肃省中药药理与毒理学重点实验室开放基金项目(No.ZDSYS-KJ-2013-010);甘肃中医药大学中青年基金项目(No.2010-11)

语种：中文

中文关键词：逍遥散;阿尔茨海默病;记忆功能;SOD;MDA;ChAT;AchE

外文关键词：Xiaoyao Powder; Alzheimer＇s disease; Memory function; SOD; MDA; ChAT; AchE

摘要：目的探讨逍遥散对D-半乳糖致阿尔茨海默病(AD)小鼠模型记忆能力及血清超氧化物歧化酶(SOD)、胆碱乙酰转移酶(ChAT)、乙酰胆碱酯酶(AchE)活性与丙二醛(MDA)水平的影响。方法 60只KM种SPF级小鼠随机分为空白组、模型组、逍遥散全方组、疏肝健脾组、疏肝养血组、健脾养血组,每组10只。腹腔注射D-半乳糖复制拟AD小鼠模型并以逍遥散全方及各配伍药组进行干预,给药第41天进行学习能力训练,第42天进行记忆功能测试,然后股动脉取血测定血清SOD、ChAT、AchE活性及MDA水平。结果逍遥散全方及各配伍药组皆可延长小鼠记忆潜伏时间,减少错误次数,提高血清SOD、ChAT活性,降低AchE活性与MDA水平,但记忆功能及血清SOD、MDA、Ch AT、Ach E的改善皆以逍遥散全方组最明显。结论逍遥散能较好地改善拟AD模型小鼠记忆功能、抗氧化能力及中枢神经递质活性。疏肝、健脾、养血是有效防治AD的统一体,缺一不可。
Objective To investigate the effect of Xiaoyao Powder on the memory function and activity of SOD,MDA,Ch AT and Ach E in serum of Alzheimer＇s disease（AD） model mice and discuss the effect and mechanism of Xiaoyao Powder on the AD and explain the compatibility mechanism of combination of Shugan,Yangxue and Jianpi of Xiaoyao Powder.Methods 60 SPF mice were divided into the blank control,model and Quanfang,Shugan Jianpi,Shugan Yangxue,Jianpi Yangxue groups,with 10 mice in each group.AD model mice was made by injecting D-gal.While,AD model mice was prevented by Quanfang,Shugan Jianpi,Shugan Yangxue,Jianpi Yangxue of Xiaoyao Powder.At the 41 st day,the ability of learning and memory training was done.At 42 nd day,the memory function was detected and then to measure content of SOD,MDA,Ch AT,Ach E in serum.Results Quanfang,Shugan Jianpi,Shugan Yangxue,Jianpi Yangxue of Xiaoyao Powder could improve memory function of AD model mice,and could improve SOD,Ch AT and decrease MDA and Ach E,but the effect of Quanfang group of Xiaoyao Powder was most obvious.Conclusions Xiaoyao powder can better improve the memory function,antioxidant activity and neurotransmitter of A D model mice,has better prevention and treatment on the AD.The Shugan,Yangxue,Jianpi is effective in preventing and treating AD prescription structure.