文献类型：期刊文献

中文题名：糖尿病肾病进展的生物学标记研究进展

英文题名：Research progress on biomarkers of progression of diabetic nephropathy

作者：王子宜[1];戴恩来[1]

第一作者：王子宜

机构：[1]甘肃中医药大学,兰州730030

第一机构：甘肃中医药大学

年份：2020

卷号：20

期号：6

起止页码：513

中文期刊名：临床肾脏病杂志

外文期刊名：Journal Of Clinical Nephrology

收录：CSTPCD

基金：国家自然科学基金地区基金(81560122)。

语种：中文

中文关键词：糖尿病肾病;终末期肾病;生物标记物

外文关键词：Diabetic nephropathy;ESRD;Biomarker

摘要：糖尿病肾病(diabetic nephropathy,DN)是糖尿病常见而严重的并发症,已经成为肾脏替代治疗的主要原因。近年来,其发病率仍然在持续上升,已成为严重影响人类健康的公共卫生问题。微量白蛋白尿被认为是肾小球和血管损伤的早期标志,也被认为是预测DN进展的指标。但是,现有临床研究表明,并非所有微量白蛋白尿阶段的糖尿病会发展为终末期肾病。因此,传统的生物标志物在判断DN进展方面仍存在一定的缺陷。因此,探索DN进展新的生物学标志,做到DN的精准诊疗是广大肾病学者关注的问题。本文就近年来DN进展的可能的生物标记物进行了综述。
Diabetic nephropathy(DN)is a common and serious complication of diabetes which has become the main cause of renal replacement therapy.In recent years,the prevalence of this disease has increased dramatically around the world and has become a leading cause of end-stage renal disease and a serious public health problem affecting human health.Microalbuminuria has been recognized as an early marker of renal glomerular and vascular injury and DN progression.However,existing clinical studies reveal that,not all diabetic patients with microalbuminuria will develop into end-stage renal failure.Therefore,traditional biomarkers still have some defects in judging the progression of diabetic nephropathy.And hence,exploring the new biological markers of DN progression or non-progression and achieving accurate diagnosis and treatment of DN are the concerns of nephrologists.In this paper,the possible biomarkers of DN progression in recent years are reviewed.