文献类型：期刊文献

英文题名：High expression level of long non-coding RNA HOTAIR is associated with poor overall survival in gastric cancer patients: evidence from meta-analysis

作者：Da, Mingxu[1];Ma, Jichun[2];Zhang, Yongbin[1];Yang, Jian[1];Yao, Jibin[1];Huang, Boyuan[3];Ma, Hong[1];Ge, Long[4]

第一作者：Da, Mingxu

通信作者：Da, MX[1]

机构：[1]Gansu Prov Hosp, Dept Surg Oncol, Dong Gang West St, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Coll Clin Med, Lanzhou, Gansu, Peoples R China;[3]Ningxia Med Univ, Coll Clin Med, Ningxia, Yinchuan, Peoples R China;[4]Lanzhou Univ, Evidence Based Med Ctr, Lanzhou, Gansu, Peoples R China

第一机构：Gansu Prov Hosp, Dept Surg Oncol, Dong Gang West St, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Surg Oncol, Dong Gang West St, Lanzhou 730000, Gansu, Peoples R China.

年份：2017

卷号：22

期号：4

起止页码：911

外文期刊名：JOURNAL OF BUON

收录：;Scopus(收录号：2-s2.0-85045578146);WOS:【SCI-EXPANDED(收录号:WOS:000412789500015)】；

基金：This study was supported by National Natural Science Foundation of China (81560391).

语种：英文

外文关键词：gastric cancer; long non-coding RNA HOTAIR; overall survival

摘要：Purpose: Although several studies have investigated the association between the development of gastric cancer (GC) and the expression level of long non-coding (Inc) RNA HO-TAIR, no clear evidence about whether its expression is associated with the overall survival (OS) of GC patients exists. In this study we tried to explore the association between IncRNA HOTAIR expression levels with OS and other clinical features in GC patients. Methods: Databases including PubMed, EMBASE and the Cochrane Library were used to search eligible studies. The quality of included studies was assessed according to reporting recommendations for tumor marker prognostic studies (REMARK). The association between the expression level of lncRNA HOTAIR and OS was evaluated by calculating the pooled hazard ratio (HR) and 95% confidence interval (95% CI) using the STATA software, version 12.0. Results: A total of 9 studies involving 740 GC and 768 normal gastric tissues were included in this meta-analysis. The average score of quality assessment was 18.89 +/- 1.08, (range 16.5-20). The results indicated that high expression levels of lncRNA HOTAIR were associated with poor OS in GC patients (pooled HR: 1.43, 95% CI:1.17-1.76, p=0.000). Subgroup analyses showed that elevated expression of lncRNA HOTAIR was significantly associated with poor OS in Chinese GC patients (HR=1.414, 95%CI: 1.120-1.785, p=0.000), and not treated GC patients (HR=1.464, 95%CI: 1.179-1.817, p =0.001). Subgroup analyses also revealed that some GC patients features (e.g. T3-T4, stage, differentiation) were associated with an unfavorable outcome. Conclusions: High expression level of lncRNA HOTAIR is associated with a poor OS in GC patients. Thus, IncRNA HOTAIR might be a potentially useful independent prognostic biomarker for GC.