文献类型：期刊文献

中文题名：度洛西汀对交通事故所致创伤后应激障碍26例患者抑郁症状的疗效分析

英文题名：The Curative Effect Analysis of Duloxetine for the Depression Symptoms of PTSD Caused by Traffic Accident

作者：彭晓明[1];郭霞[1];张震文[2]

第一作者：彭晓明

机构：[1]甘肃中医学院附属医院,甘肃兰州730020;[2]甘肃中医学院

第一机构：甘肃中医药大学第二附属医院

年份：2011

卷号：23

期号：23

起止页码：2937

中文期刊名：中国民康医学

外文期刊名：Medical Journal of Chinese People’s Health

语种：中文

中文关键词：交通事故所致创伤后应激障碍;度洛西汀;帕罗西汀;疗效观察

外文关键词：The post -traumatic stress disorder caused by the traffic accident, Duloxetine, Paroxetine, Curative effects

摘要：目的:探讨度洛西汀和帕罗西汀对交通事故所致创伤后应激障碍患者抑郁症状的疗效与安全性。方法:将52例患者随机分为度洛西汀治疗组(研究组)26例与帕罗西汀治疗组(对照组)26例,疗程8周,分别于治疗前和治疗后采用汉密顿抑郁量表(HAMD)和临床疗效总评量表(CGI)、不良反应量表(TESS)评定临床疗效和不良反应。结果:度洛西汀在治疗后起效快于帕罗西汀组,有效率与帕罗西汀组相当,而且不良反应较少。结论:度洛西汀治疗创伤后应激障碍效果相当于帕罗西汀,但其不良反应少于帕罗西汀。
Objective：To study the cruative effect and safety of the duloxetine and paroxetine for the depressed patients of post - traumatic stress disorder caused by traffic accident. Methods ： There are 52 subjects in the experiment. The participants were devided into two groups randomly - -the treatment group（26） is treated by the duloxetine, and the control group （26） is treated by the paroxetine. The treatment was carried out eight weeks, and the ham - d （ HAMD）, the clinical curative effect we scale （CGI） and the side effects scale （TESS） were applied into the whole treatment to assess the clinical effect and adverse reactions. Results： In the end of the experiment, the efficient of the two groups is in the same degree. However, compared with the paroxetine group, the duloxetine group produced the desired result, and there is less adverse reaction. Conclusions： the therapeutic effect of the duloxetine is equivalent to the paroxetine for the post - traumatic stress disorder, but the adverse reactions of the duloxetine are less than paroxetine.