文献类型：期刊文献

中文题名：“肝脾失调-伏毒损络”与代谢相关脂肪性肝病“多重打击”学说对应关系探讨

英文题名：Exploration on correspondence between“liver and spleen disharmony latent pathogenic factors damaging collaterals”and“multiple-strike”theory of metabolic associated fatty liver disease

作者：郭欣[1];刘俊宏[2];李红梅[1];张娟[1];徐冰蕊[1]

第一作者：郭欣

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000;[2]甘肃中医药大学附属医院脾胃病科,甘肃兰州730020

第一机构：甘肃中医药大学中西医结合学院

年份：2026

卷号：23

期号：5

起止页码：171

中文期刊名：中国医药导报

外文期刊名：China Medical Herald

基金：国家中医药管理局青年岐黄学者基金项目(国中医药人教函[2022]256号);甘肃省科技计划(创新基地和人才计划)项目(21JR7RA682)。

语种：中文

中文关键词：代谢相关脂肪性肝病;肝脾失调;伏毒内生;络脉损伤;“多重打击”学说

外文关键词：Metabolic associated fatty liver disease;Liver and spleen disharmony;Latent pathogenic factors endogeny;Collateral damage;“Multiple-strike”theory

摘要：代谢相关脂肪性肝病作为全球高发的慢性代谢性疾病,其发病机制复杂且缺乏特效药物。本文基于中医“肝脾相关”与“伏毒损络”理论,探讨“肝脾失调-伏毒内生-络脉损伤”的病机演变与代谢相关脂肪性肝病“多重打击”学说对应关系:肝脾失调作为代谢紊乱的始动病机,对应“初次打击”的胰岛素抵抗与脂代谢紊乱;湿、痰、瘀、浊久蕴化毒形成“伏毒内生”,对应“二次打击”的氧化应激和炎症级联反应;络脉损伤致微循环障碍与结构破坏,对应“终末打击”的肝纤维化。该理论为代谢相关脂肪性肝病分期辨证提供理论依据,为其防治提供新思路。
Metabolic associated fatty liver disease as a globally prevalent chronic metabolic disease,has a complex pathogenesis,and lacks specific drugs.This article is based on theories of“liver and spleen correlation”and“latent pathogenic factors damaging collaterals”in traditional Chinese medicine,explores correspondence between pathological evolution of“liver and spleen disharmony-latent pathogenic factors endogeny-collateral damage”and“multiple-strike”theory of metabolic associated fatty liver disease:liver and spleen disharmony as initiating pathogenesis of metabolic disorders,corresponds to insulin resistance and lipid metabolism disorders in“the first strike”;dampness,phlegm,blood stasis,and turbidity accumulate for a long time to form a“latent pathogenic factors endogeny”,corresponding to oxidative stress,and inflammatory cascade reaction of“the second strike”;collateral damage leads to microcirculatory disorders and structural damage,corresponding to liver fibrosis caused by“terminal strike”.This theory provides a theoretical basis for staged differentiation of syndromes in metabolic related fatty liver disease,and offers new ideas for its prevention and treatment.