文献类型：期刊文献

英文题名：Clinical application of parathyroid autotransplantation in endoscopic radical resection of thyroid carcinoma

作者：Zhang, Qi[1];Qu, Kun-Peng[2];Wang, Ze-Sheng[1];Gao, Jing-Wei[1];Zhang, Yu-Peng[2];Cao, Wei-Jia[2]

第一作者：张倩;张青;张茜;张芹

通信作者：Qu, KP[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Peoples Hosp, Dept Gen Surg, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Dept Gen Surg, Lanzhou, Peoples R China.

年份：2022

卷号：12

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85136979419);WOS:【SCI-EXPANDED(收录号:WOS:000843465400001)】；

基金：Funding This work was supported by following grants: Natural Science Foundation of Gansu Province of China(145RJZA116); Special Fund for Clinical Research of Wu Jieping Medical Foundation (320.6750.16216)

语种：英文

外文关键词：endoscopic radical resection of thyroid carcinoma; parathyroid autotransplantation; transient hypoparathyroidism; permanent hypoparathyroidism; central lymph node dissection

摘要：PurposeThis study aimed to examine the effect of selective inferior parathyroid gland autotransplantation on central lymph node dissection(CLND) and incidence of postoperative hypoparathyroidism in patients undergoing endoscopic radical resection of thyroid carcinoma. MethodsThe data of 310 patients undergoing endoscopic radical resection of thyroid carcinoma will be retrospectively analyzed. The patients will be divided into the experimental group and the control group according to whether they combined with parathyroid autotransplantation. Statistics of the incidence rate of postoperative hypoparathyroidism, the concentration of PTH and Calcium in the systemic circulation at different time points in the two groups, the concentration of PTH in the cubital fossa vein in the transplantation region in the experimental group, and the number of central lymph nodes and positive lymph nodes dissection will be carried out. ResultsThe incidence rate of temporary and permanent hypoparathyroidism in the experimental group was 33.75% and 0.625%, respectively, and in the control group was 22% and 5%, respectively; its difference was statistically significant (X-2 = 10.255, P=0.006). Parathyroid autotransplantation increased incidence of transient hypoparathyroidism (OR, 1.806; Cl, 1.088-2.998; P=0.022), and lower incidence of permanent hypoparathyroidism (OR, 0.112; Cl, 0.014-0.904; P=0.040). The diameters of thyroid cancer nodules was not associated with the occurrence of transient hypoparathyroidism (OR, 0.769; Cl, 0.467-1.265; P=0.301) or permanent hypoparathyroidism (OR, 1.434; Cl, 0.316-6.515; P=0.641). Comparison of systemic circulation PTH, between the two groups showed that the PTH of patients in the experimental group was higher than that in the control group from 1 week to 12 months after the operation, and the difference was statistically significant (P<0.05). In the experimental group, from 1 week to 12 months after surgery, PTH concentrations was significantly higher in the cubital fossa of the transplantation side than in the contralateral side, and the differences were statistically significant (P<0.05). The mean number of central lymph node dissected per patient was significantly higher in the experimental group (7.94 +/- 3.03 vs. 6.99 +/- 2.86; P <0.05); The mean number of positive nodes per patient was significantly higher in the experimental group (3.16 +/- 1.86 vs. 2.53 +/- 1.59; P <0.05). ConclusionsIn endoscopic radical resection of thyroid carcinoma, parathyroid autotransplantation is more beneficial to postoperative parathyroid glands function recovery, effectively preventing postoperative permanent hypoparathyroidism and realizing more thorough CLND.