文献类型：期刊文献

英文题名：The mechanism of dendritic cell-T cell crosstalk in rheumatoid arthritis

作者：Wang, Zhandong[1];Zhang, Jinlong[2];An, Fangyu[3];Zhang, Jie[4];Meng, Xiangrui[2];Liu, Shiqing[1];Xia, Ruoliu[2];Wang, Gang[5];Yan, Chunlu[1]

第一作者：Wang, Zhandong

通信作者：Yan, CL[1];Wang, G[2]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Rheumatism & Orthopaed Dept, Affiliated Hosp, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Rheumatism & Orthopaed Dept, Affiliated Hosp, Lanzhou 730000, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2023

卷号：25

期号：1

外文期刊名：ARTHRITIS RESEARCH & THERAPY

收录：;Scopus(收录号：2-s2.0-85173742330);WOS:【SCI-EXPANDED(收录号:WOS:001080745500001)】；

基金：This present study got grants from the National Natural Science Foundation of China (81860858) and the Natural Science Program in Gansu Province (22JR5RA573).

语种：英文

外文关键词：Rheumatoid arthritis; Dendritic cells; Chemokines; PD-L1/PD-1 signalling axis; TGF-beta signalling axis; Crosstalk mechanism

摘要：Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by joint pain and swelling, synovial hyperplasia, cartilage damage, and bone destruction. The mechanisms of dendritic cell (DC) and T cell-mediated crosstalk have gradually become a focus of attention. DCs regulate the proliferation and differentiation of CD4(+) T cell subtypes through different cytokines, surface molecules, and antigen presentation. DC-T cell crosstalk also blocks antigen presentation by DCs, ultimately maintaining immune tolerance. DC-T cell crosstalk mainly involves chemokines, surface molecules (TonEBP, NFATc1), the PD-L1/PD-1 signalling axis, and the TGF-beta signalling axis. In addition, DC-T cell crosstalk in RA is affected by glycolysis, reactive oxygen species, vitamin D, and other factors. These factors lead to the formation of an extremely complex regulatory network involving various mechanisms. This article reviews the key immune targets of DC-T cell crosstalk and elucidates the mechanism of DC-T cell crosstalk in RA to provide a basis for the treatment of patients with RA.