文献类型：期刊文献

英文题名：HLA class I and II alleles in susceptibility to ankylosing spondylitis

作者：Reveille, John D.[1];Zhou, Xiaodong[1];Lee, Minjae[2];Weisman, Michael H.[3];Yi, Lin[4];Gensler, Lianne S.[5];Zou, Hejian[6];Ward, Michael M.[7];Ishimori, Mariko L.[3];Learch, Thomas J.[3];He, Dongyi[8];Rahbar, Mohammad H.[2];Wang, Jiucun[6];Brown, Matthew A.[9]

第一作者：Reveille, John D.

通信作者：Reveille, JD[1]

机构：[1]Univ Texas Hlth Sci Ctr Houston, Div Rheumatol & Clin Immunogenet, McGovern Med Sch, Houston, TX 77030 USA;[2]Univ Texas Hlth Sci Ctr Houston, Div Clin & Translat Sci, McGovern Med Sch, Houston, TX 77030 USA;[3]Cedars Sinai Med Ctr, Dept Radiol, Los Angeles, CA 90048 USA;[4]Gansu Coll Tradit Chinese Med, Div Rheumatol, Lanzhou, Gansu, Peoples R China;[5]Univ Calif San Francisco, Div Rheumatol, San Francisco, CA 94143 USA;[6]Fudan Univ, Huashan Hosp, Shanghai, Peoples R China;[7]Natl Inst Arthrit & Musculoskeletal & Skin Dis, Div Rheumatol, Bethesda, MD USA;[8]Shanghai Guanghua Hosp, Div Rheumatol, Shanghai, Peoples R China;[9]Queensland Univ Technol, Princess Alexandra Hosp, Inst Hlth & Biomed Innovat, Translat Res Inst, Brisbane, Qld, Australia

第一机构：Univ Texas Hlth Sci Ctr Houston, Div Rheumatol & Clin Immunogenet, McGovern Med Sch, Houston, TX 77030 USA

通信机构：[1]corresponding author), Univ Texas Houston, Hlth Sci Ctr, Div Rheumatol & Clin Immunogenet, Houston, TX 77030 USA.

年份：2019

卷号：78

期号：1

起止页码：66

外文期刊名：ANNALS OF THE RHEUMATIC DISEASES

收录：;Scopus(收录号：2-s2.0-85055247665);WOS:【SCI-EXPANDED(收录号:WOS:000455953500021)】；

基金：This study was supported by the National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIH-NIAIS) grant UO1 AI09090 (Drs Zhou, Reveille), National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIH-NIAMS) grants R01 AR-46208 and 2P01AR052915-06A1 (Dr Reveille) and by University Clinical Research Grants M01-RR-02558 (The University of Texas Health Science Center at Houston) and M01-RR-000425 (Cedars-Sinai Medical Center) and by a grant from the Spondylitis Association of America. MAB was funded by a National Health and Medical Research Council (Australia) Senior Principal Research Fellowship. LSG is supported by the Rosalind Engelman Research Center at the University of California, San Francisco. MMW is funded by the Intramural Research Program, NIAMS/NIH.

语种：英文

外文关键词：African-American; Chinese; disease susceptibility; ethnicity; HLA; spondylitis; uveitis

摘要：Objective To examine associations of HLA class I and class II alleles with ankylosing spondylitis (AS) in three cohorts of patients of European, Asian and African ancestry. Methods HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 and HLA-DPB1 alleles were genotyped in 1948 unrelated white and 67 African-American patients with AS from the Prospective Study of Outcomes in Ankylosing Spondylitis cohort, the North American Spondylitis Consortium and Australo-Anglo-American Spondyloarthritis Consortium, 990 white and 245 African-American Controls and HLA-B alleles in 442 Han Chinese patients with AS and 346 controls from Shanghai and Gansu, China. In addition to the case: control analyses, HLA-B(star)27-negative patients with AS were analysed separately, and logistic regression and ' relative predispositional effects' (RPE) analyses were carried out to control for the major effect of HLA-B(star)27 on disease susceptibility. Results A lthough numerous associations were seen between HLA alleles and AS in whites, among HLA-B(star)27-negative patients with AS, positive associations were seen with HLA-A(star)29, B(star)38, B(star)49, B(star)52, DRB1(star)11 and DPB1(star)03:01 and negative associations with HLA-B(star)07, HLA-B(star)57, HLA-DRB1(star)15:01, HLA-DQB1(star)02:01 and HLA-DQB1(star)06:02. Additional associations with HLA-B(star)14 and B(star)40 (B60) were observed via RPE analysis, which excludes the HLA-B(star)27 alleles. The increased frequency of HLA-B(star)40:01 and decreased frequency of HLA-B(star)07 was also seen in Han Chinese and African-Americans with AS. HLA-B(star)08 was decreased in whites with acute anterior uveitis. Conclusions These data, analysing the largest number of patients with AS examined to date in three ethnic groups, confirm that other HLA class I and II alleles other than HLA-B(star)27 to be operative in AS predisposition.