文献类型：期刊文献

中文题名：安寐颗粒对失眠伴高血压虚证型患者睡眠质量及血压昼夜节律的影响

英文题名：Effects of Anmei Granules on sleep quality and blood pressure circadian rhythm in insomnia with hypertension patients with deficiency syndrome

作者：于小刚[1];辛二旦[2];杨文媛[1];黄进学[1];和芳娟[1];汪国荣[2];高亮丽[2];卢玉俊[1,2]

第一作者：于小刚

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院,兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：38

期号：2

起止页码：891

中文期刊名：中华中医药杂志

外文期刊名：China Journal of Traditional Chinese Medicine and Pharmacy

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家重点研发计划(No.2018YFC1705600);甘肃省中医药防治重大疾病科研课题(No.GZKZD-2018-2)。

语种：中文

中文关键词：安寐颗粒;失眠伴高血压;虚证;匹兹堡睡眠质量指数;SPIEGEL量表;晨峰血压;血压变异性;昼夜节律

外文关键词：Anmei Granules;Insomnia with hypertension;Deficiency syndrome;Pittsburgh sleep quality index;SPIEGEL scale;Morning peak blood pressure;Blood pressure variability;Circadian rhythm

摘要：目的:探讨安寐颗粒治疗失眠伴高血压虚证型患者睡眠质量及血压昼夜节律的影响,评价其临床疗效。方法:将120例患者随机分为观察组和对照组,每组60例,两组患者均给予睡眠卫生宣教和降压基础治疗,观察组口服安寐颗粒,对照组口服模拟剂,疗程为4周;比较两组患者治疗前后匹兹堡睡眠质量指数(PSQI)评分、SPIEGEL量表、晨峰血压及血压变异性的差异,并记录不良反应,进行临床疗效判定。结果:观察组脱落3例,完成观察57例;对照组脱落8例,完成观察52例。观察组治疗失眠的总有效率(89.47%,51/57)显著高于对照组(21.15%,11/52)(P<0.05);观察组治疗后PSQI评分和SPIEGEL量表评分较治疗前显著降低(P<0.05),且低于对照组(P<0.05);两组患者治疗后晨峰血压较治疗前均显著降低(P<0.05)。结论:安寐颗粒能有效改善失眠伴高血压虚证型患者睡眠质量,而对血压昼夜节律无明显影响。
Objective:To investigate the effects of Anmei Granules on sleep quality and circadian rhythm of blood pressure in insomnia with hypertension patients with deficiency sydrome and to evaluate its clinical efficacy.Methods:A total of 120 patients were randomly divided into the observation group and the control group,60 patients in each group.Both groups were given sleep hygiene education and basic antihypertensive treatment,and the observation group was given Anmei Granules orally while the control group was given placebo orally for 4 weeks.The differences in PSQI score,SPIEGEL scale,morning peak blood pressure and blood pressure variability between the two groups before and after treatment were compared,and adverse effects were recorded.Clinical efficacy was determined.Results:In the observation group,there were 3 cases of shedding and 57 cases of completion of observation;in the control group,there were 8 cases of shedding and 52 cases of completion of observation.The overall effective rate of treatment for insomnia was higher in the observation group(89.47%,51/57)than in the control group(21.15%,11/52)(P<0.05).The PSQI score and the SPIEGEL scale score decreased in the observation group after treatment compared with those before treatment(P<0.05),and decreased compared with those after treatment(P<0.05).The morning peak blood pressure decreased after treatment in both groups compared with that before treatment(P<0.05).Conclusion:Anmei Granules can effectively improve the sleep quality of patients with insomnia with hypertension in the deficiency syndrome,without any significant effect on the circadian rhythm of blood pressure.