文献类型：期刊文献

英文题名：Phytochemical-rich Eucommia ulmoides leaf extract extends healthspan in Caenorhabditis elegans via the pmk-1/p38 MAPK pathway and mitochondrial homeostasis

作者：Zhang, Jiaxu[1,2];Ma, Quhuan[1];Li, Jiaojiao[2];Xie, Xingwen[3];Shi, Xiaofeng[1,2]

第一作者：张菊秀;张静霞;张建勋;Zhang, Jiaxu

通信作者：Shi, XF[1];Shi, XF[2];Xie, XW[3]

机构：[1]Inst Pharmaceut Res, Gansu Prov Acad Inst Med Res, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Peoples R China

第一机构：Inst Pharmaceut Res, Gansu Prov Acad Inst Med Res, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Inst Pharmaceut Res, Gansu Prov Acad Inst Med Res, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;

年份：2025

卷号：12

外文期刊名：FRONTIERS IN NUTRITION

收录：;Scopus(收录号：2-s2.0-105021345593);WOS:【SCI-EXPANDED(收录号:WOS:001610067400001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by the Gansu Provincial Traditional Chinese Medicine Industry Innovation Consortium Project, Grant Number 22ZD6FA021-4.

语种：英文

外文关键词：Eucommia ulmoides leaf; Caenorhabditis elegans; healthspan; mitochondrion; MAPK

摘要：Objectives As a medicinal and edible resource, Eucommia ulmoides leaf (EUL) shows considerable promise in facilitating healthy aging. However, its precise biological mechanisms remain unclear. This study aimed to investigate the anti-aging efficacy and underlying pathways of Eucommia ulmoides leaf extract (EULE) using the Caenorhabditis elegans (C. elegans) model.Methods Phytochemical profiling of the extract was performed. C. elegans were supplemented with the extract, and the effects on lifespan, healthspan indicators (muscle deterioration, intestinal barrier function, mitochondrial homeostasis), and gene expression were evaluated via transcriptomic analysis.Results Phytochemical analysis revealed that the extract is abundant in bioactive compounds such as flavonoids, iridoids, and lignans. Supplementation with the extract significantly prolonged the lifespan of C. elegans by up to 14.69% and improved healthspan by alleviating age-related muscle deterioration, preserving intestinal barrier function, and regulating mitochondrial homeostasis. Transcriptomic analysis identified the mitogen activated protein kinase (MAPK) signaling pathway as the primary mediator of these anti-aging benefits.Conclusions These results provide robust evidence supporting the use of EUL as a natural dietary supplement to prolong healthspan, establishing a scientific rationale for its application in promoting healthy aging.