文献类型：期刊文献

中文题名：活血定眩胶囊对CSA模型大鼠椎动脉血流量及血浆PAI、t-PA水平的影响

英文题名：Effects of Huoxue Dingxuan Capsule Glare on Vertebral Artery Blood Flow,Plasma PAI and t-PA in CSA Rat Models

作者：李清林[1];宋敏[1];孙定平[1];孙彬霄[2];刘涛[1];巩彦龙[1];柴居堂[3];刘晓[1]

第一作者：李清林

机构：[1]甘肃中医药大学中医临床学院;[2]中国中医科学院;[3]甘肃中医药大学附属医院骨科

第一机构：甘肃中医药大学中医临床学院

年份：2016

卷号：47

期号：6

起止页码：862

中文期刊名：四川大学学报：医学版

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；PubMed;

基金：国家自然科学基金(No.81360554);甘肃省中药现代制药工程研究院开发项目(No.230583306);甘肃省重点中医药科研立项课题(No.GZK-2010-Z14);甘肃省高等学校研究生导师科研项目(No.1206-01)资助

语种：中文

中文关键词：活血定眩胶囊;椎动脉型颈椎病;PAI;t-PA

外文关键词：Huoxue Dingxuan Capsule ;Cervical spondylosis of vertebral artery type; PAI; t-PA

摘要：目的探究活血定眩胶囊对椎动脉型颈椎病(cervical spondylosis of vertebral artery type,CSA)模型大鼠椎动脉血流量以及血浆中组织型纤溶酶原激活物(tissue type plasminogen activator,t-PA)和纤溶酶原激活物抑制物(plasminogen activator inhibitor,PAI)的影响。方法将90只健康雄性Wistar大鼠随机分为对照组、模型组及治疗组3组,每组30只。对照组不做处理,模型组及治疗组采用复合造模法制造CSA模型大鼠。治疗组在造模4周后按照人鼠折算系数开始给予活血定眩胶囊药物干预6周。每组分别在造模前、干预前及干预后3个不同时间点检测椎动脉血流量及血浆PAI、t-PA含量。结果干预前,模型组与治疗组的椎动脉血流量均低于对照组(P<0.05);干预后,治疗组高于对照组(P<0.05)。与本组造模前分别比较,模型组及治疗组干预前血清PAI、tPA含量均升高(P<0.01)。与对照组同期比较,模型组及治疗组干预前PAI、t-PA含量升高(P<0.01)。与本组干预前进行比较,模型组造模后血清PAI、t-PA含量升高(P<0.01),治疗组干预后血清PAI、t-PA含量降低(P<0.01)。与模型组同期比较,治疗组干预后血清PAI、t-PA含量降低(P<0.01)。结论活血定眩胶囊可提高椎动脉血流量,降低血清PAI、t-PA含量。
Objective To determine the effects of Huoxue Dingxuan Capsule on vertebral artery blood flow, plasma piasminogen activator （t-PA） and plasminogen activator inhibitor （PAI） in rats with cervical spondylosis of vertebral artery type （CSA）. Methods Ninety healthy male Wistar rats were equally and randomly divided into control, model and treatment groups. The rats in the model and treatment groups were subject to composite modeling manufacturing CSA. The treatment group was given six-week interventions with Huoxue Dingxuan capsule 4 weeks after the modeling. Vertebral artery blood flow, plasma PAI, and t-PA contents were detected before modeling, prior to the interventions, and post interventions. Results Before the interventions, the rats in the model and treatment groups had significantly lower blood flow of vertebral artery than the controls （P〈0. 05）. The model rats also had increased serum PAI and t-PA contents （P〈0. 01）. After the interventions, significantly higher vertebral blood flow was found in the treatment group compared with the controls （P〈0. 05）. After the interventions, increased serum PAI and t-PA contents were observed in the rats in the model group （P〈0. 01）; whereas, decreased serum PAI and t-PA contents were observed in the rats in the treatment group （P〈0.01）. The treatment group had lower levels of serum PAI and t-PA contents than the model group （P〈0. 01）. Conclusion Huoxue Dingxuan Capsule glare can improve the blood flow of vertebral artery and reduce serum PAI and t-PA contents.