文献类型：期刊文献

英文题名：Phenylethanoid glycosides of Pedicularis muscicola Maxim ameliorate high altitude-induced memory impairment

作者：Zhou, Baozhu[1,2];Li, Maoxing[1,2,3];Cao, Xinyuan[1,2];Zhang, Quanlong[1];Liu, Yantong[1];Ma, Qiang[1];Qiu, Yan[4];Luan, Fei[1,3];Wang, Xianmin[1]

第一作者：Zhou, Baozhu

通信作者：Li, MX[1]

机构：[1]Lanzhou Gen Hosp PLA, Key Lab Prevent & Treatment Injury Plateau PLA, Dept Pharm, Lanzhou 730050, Peoples R China;[2]Lanzhou Univ, Dept Pharm, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Dept Pharm, Lanzhou 730000, Peoples R China;[4]454th Hosp PLA, Dept Pharm, Nanjing 210002, Jiangsu, Peoples R China

第一机构：Lanzhou Gen Hosp PLA, Key Lab Prevent & Treatment Injury Plateau PLA, Dept Pharm, Lanzhou 730050, Peoples R China

通信机构：[1]corresponding author), Lanzhou Gen Hosp PLA, Dept Pharm, Key Discipline Tradit Chinese Med, 333 South Binghe Rd, Lanzhou, Peoples R China.

年份：2016

卷号：157

起止页码：39

外文期刊名：PHYSIOLOGY & BEHAVIOR

收录：;Scopus(收录号：2-s2.0-84956661605);WOS:【SSCI(收录号:WOS:000372943000006)，SCI-EXPANDED(收录号:WOS:000372943000006)】；

基金：This study was supported by the special project of the "Twelfth Five-year Plan" for Medical Science Development of PLA (BWS12J012), the Project of Traditional Chinese Medicine Administration, Gansu Province (GZK-2015-59), and the Project of Military Medical and Health Research, PLA (CLZ15JA05, CLZ15JB04, 15ZD021).

语种：英文

外文关键词：Phenylethanoid glycosides; Pedicularis muscicola Maxim; Oxidative stress; Memory impairment; Degeneration; Apoptosis; Hippocampus

摘要：Exposure to hypobaric hypoxia causes oxidative stress, neuronal degeneration and apoptosis that leads to memory impairment Though oxidative stress contributes to neuronal degeneration and apoptosis in hypobaric hypoxia, the ability for phenylethanoid glycosides of Pedicularis muscicola Maxim (PhGs) to reverse high altitude memory impairment has not been studied. Rats were supplemented with PhGs orally for a week. After the fourth day of drug administration, rats were exposed to a 7500 m altitude simulation in a specially designed animal decompression chamber for 3 days. Spatial memory was assessed by the 8-arm radial maze test before and after exposure to hypobaric hypoxia. Histological assessment of neuronal degeneration was performed by hematoxylineosin (HE) staining. Changes in oxidative stress markers and changes in the expression of the apoptotic marker, caspase-3, were assessed in the hippocampus. Our results demonstrated that after exposure to hypobaric hypoxia, PhGs ameliorated high altitude memory impairment, as shown by the decreased values obtained for reference memory error (RME), working memory error (WME), and total error (TE). Meanwhile, administration of PhGs decreased hippocampal reactive oxygen species levels and consequent lipid peroxidation by elevating reduced glutathione levels and enhancing the free radical scavenging enzyme system. There was also a decrease in the number of pyknotic neurons and a reduction in caspase-3 expression in the hippocampus. These findings suggest that PhGs may be used therapeutically to ameliorate high altitude memory impairment (C) 2016 Elsevier Inc. All rights reserved.