文献类型：期刊文献

英文题名：Optimal obesity and lipid-related predictors of diabetes mellitus in middle-aged and elderly patients with liver disease in China: a CHARLS cross-sectional study

作者：Wu, Yang[1,2,4];Li, Tian[2,5];Zhang, Yanan[1,2];Wu, Chujiang[1,2];Zheng, Xiaofeng[3];Zhang, Jiucong[1];Liang, Bing[4]

第一作者：Wu, Yang;武燕;吴艳

通信作者：Zhang, JC[1];Liang, B[2]

机构：[1]940th Hosp Joint Logist Support Force PLA, Dept Gastroenterol, Lanzhou 730050, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Dept Orthopaed, Hosp 2, Lanzhou 730000, Gansu, Peoples R China;[4]Pengzhou Jiuchi Town Hosp, Chengdu 611930, Sichuan, Peoples R China;[5]Qianfeng Dist Tradit Chinese Med Hosp, Guangan 638019, Sichuan, Peoples R China

第一机构：940th Hosp Joint Logist Support Force PLA, Dept Gastroenterol, Lanzhou 730050, Gansu, Peoples R China

通信机构：[1]corresponding author), 940th Hosp Joint Logist Support Force PLA, Dept Gastroenterol, Lanzhou 730050, Gansu, Peoples R China;[2]corresponding author), Pengzhou Jiuchi Town Hosp, Chengdu 611930, Sichuan, Peoples R China.

年份：2025

卷号：16

期号：4

起止页码：834

外文期刊名：DIABETOLOGY INTERNATIONAL

收录：Scopus(收录号：2-s2.0-105016711513);WOS:【ESCI(收录号:WOS:001575237100001)】；

基金：Tutor Program at Gansu University of Traditional Chinese Medicine (2023YXKY020); Lanzhou Youth Science and Technology Talents Innovation Project (2024-QN-39).

语种：英文

外文关键词：China middle-aged and elderly people; Patients with liver disease; Diabetes; Obesity and lipid-related indicators; CHARLS

摘要：Introduction Chinese middle-aged and elderly (>= 45 years old) liver disease patients have a high diabetes mellitus (DM) incidence with gender differences. Identify the optimal obesity and blood lipid-related predictors of DM in such patients by sex. Methods Using China Health and Retirement Longitudinal Study (CHARLS) 2011-2020 data, we explored DM predictors by sex, evaluating with receiver operating characteristic (ROC), area under curve (AUC), etc., to calculate odds ratio (OR) and 95% confidence interval (CI) after confounder adjustment. Results Many indexes were significant (P < 0.05). Obesity and lipid-related indexes had certain discrimination (AUC > 0.5), with the triglyceride-glucose (TyG) index performing best (AUC = 0.78). The visceral adiposity index (VAI) (OR = 1.08, 95%CI = 1.04-1.12) and the triglyceride-glucose-body mass index (TyG-BMI) (OR = 1.14, 95%CI = 1.06-1.22) promoted DM in male patients, while VAI (OR = 1.12, 95%CI = 1.08-1.16) and the triglyceride-glucose-waist circumference (TyG-WC) (OR = 1.15, 95%CI = 1.09-1.21) did so in female patients. Conclusion TyG-BMI and TyG-WC are the best DM predictors for male and female liver disease patients, respectively. VAI also has predictive value for DM prevention.