文献类型：期刊文献

英文题名：Unraveling the gut microbiota's role in salt-sensitive hypertension: current evidences and future directions

作者：Wang, Li[1];Hu, Jihong[2,3]

第一作者：王丽;王莉;王力

通信作者：Hu, JH[1];Hu, JH[2]

机构：[1]Gansu Univ Chinese Med, Publ Hlth Sch, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Key Lab Dunhuang Med, Minist Educ, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Key Lab Dunhuang Med, Minist Educ, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：11

外文期刊名：FRONTIERS IN CARDIOVASCULAR MEDICINE

收录：;Scopus(收录号：2-s2.0-85200057995);WOS:【SCI-EXPANDED(收录号:WOS:001281365500001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article.This article was funded by the National Natural Science Foundation of China (81960614); Key Research and Development Program of International Science and Technology Cooperation in Gansu Province(20YF3WA020); Open Project of Dunhuang Key Laboratory of Medicine and Transformation of Ministry of Education (DHYX20-05).

语种：英文

外文关键词：gut microbiota; hypertension; salt sensitivity; TH17; SSH

摘要：The gut microbiota plays a pivotal role in both maintaining human health and in the pathogenesis of diseases. Recent studies have brought to light the significant correlation between gut microbiota and hypertension, particularly focusing on its role in the development and advancement of SSH, a subtype characterized by elevated blood pressure in response to high salt consumption. The complexity of SSH's etiology is notable, with dysbiosis of the gut microbiome identified as a crucial contributing factor. The gut microbiota participates in the occurrence and development of SSH by affecting the host's immune system, metabolic function, and neuromodulation. Investigations have demonstrated that the gut microbes regulate the development of SSH by regulating the TH17 axis and the activity of immune cells. Moreover, microbial metabolites, such as short-chain fatty acids, are implicated in blood pressure regulation and affect the development of SSH. There is evidence to show that the composition of the gut microbiome can be altered through prebiotic interventions so as to prevent and treat SSH. This review aims to concisely sum up the role of gut microbiota in SSH and to discuss pertinent therapeutic strategies and clinical implications, thereby providing a valuable reference for further research and clinical practice in this area.