文献类型：期刊文献

英文题名：Decarboxylative Suzuki-Miyaura coupling of (hetero)aromatic carboxylic acids using iodine as the terminal oxidant

作者：Quibell, Jacob M.[1];Duan, Guojian[1,2];Perry, Gregory J. P.[1];Larrosa, Igor[1]

第一作者：Quibell, Jacob M.

通信作者：Larrosa, I[1]

机构：[1]Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England;[2]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China

第一机构：Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England

通信机构：[1]corresponding author), Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England.

年份：2019

卷号：55

期号：45

起止页码：6445

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;Scopus(收录号：2-s2.0-85066448555);WOS:【SCI-EXPANDED(收录号:WOS:000471038300021)，CCR-EXPANDED(收录号:WOS:000471038300021)】；

基金：We gratefully acknowledge the University of Manchester School of Chemistry for funding (to G. J. P. P.). We also thank the National Natural Science Foundation of China (No. 21762001) and the China Scholarship Council for a visiting scholarship (to G. D.).

语种：英文

摘要：A novel methodology for the decarboxylative Suzuki-Miyaura-type coupling has been established. This process uses iodine or a bromine source as both the decarboxylation mediator and the terminal oxidant, thus avoiding the need for stoichiometric amounts of transition metal salts previously required. Our new protocol allows for the construction of valuable biaryl architectures through the coupling of (hetero)aromatic carboxylic acids with arylboronic acids. The scope of this decarboxylative Suzuki reaction has been greatly diversified, allowing for previously inaccessible non-ortho-substituted aromatic acids to undergo this transformation. The procedure also benefits from low catalyst loadings and the absence of stoichiometric transition metal additives.