文献类型：期刊文献

中文题名：健脾养胃法治疗慢性萎缩性胃炎的Meta分析

英文题名：Meta-analysis of Spleen And Stomach Method in Treatment of Chronic Atrophic Gastritis

作者：张鹏[1];汪龙德[2];晁荣[3];杨晓轶[1]

第一作者：张鹏

机构：[1]甘肃中医药大学;[2]甘肃中医药大学附属医院;[3]甘肃省妇幼保健院

第一机构：甘肃中医药大学

年份：2017

卷号：15

期号：6

起止页码：3

中文期刊名：中国老年保健医学

外文期刊名：Chinese Journal of Geriatric Care

基金：基金项目:甘肃中医药管理局[cdx2;survivin;pten基因在胃癌癌前病变中医证型中的表达及相关性研究(GZK-2011-7)];甘肃省科技厅[以益气健脾为主的中医不同治法对胃癌癌前病变模型大鼠相关基因表达的影响(1208RJZA181)]

语种：中文

中文关键词：慢性萎缩性胃炎;健脾养胃;疗效;Meta分析;随机对照试验

外文关键词：Chronic atrophic gastritis, Spleen and stomach, Curative effect, Meta analysis, Randomized controlled trial

摘要：目的应用Meta分析系统评价健脾养胃法治疗慢性萎缩性胃炎(chronic atrophic gastritis,CAG)的疗效。为健脾养胃法治疗CAG提供重要的临床循证医学证据。方法系统检索中国生物医学文献数据库、维普、万方、Cochrane图书馆、Pub Med、中国知网、中国期刊网(数据为2000年1月至2017年4月),以健脾养胃法与其他疗法的随机对照实验为研究对象,按照纳入排除标准选择文献、提取资料,由2名评价员按Jadad量评分法对纳入的文献进行质量评价并进行资料提取,用Rev Man 5.3软件进行Meta分析。结果共纳入11篇文章,所有纳入文献的Jadad评分均为1～2分,合计759例患者。Meta分析结果显示:单纯健脾养胃法中药治疗组的临床总有效率优于单纯西医药物或中成药治疗组,其差异有统计学意义[OR=4.30,95%CI(2.81～6.58),P<0.00001];试验组的胃镜改善率优于对照组,其差异有统计学意义[OR=3.36,95%CI(1.70～6.64),P=0.0005];试验组的病理改善有效率优于对照组,其差异有统计学意义[OR=3.99,95%CI(2.47～6.46),P<0.00001]。结论健脾养胃法治疗CAG在临床症状改善方面、胃镜改善方面及病理改善方面均优于对照组,且总体疗效优于对照组,但纳入文献的质量较低,确切结论尚需更高质量的试验证实。
Objectives To evaluate the efficacy of using spleen and stomach method in treatment of Chronic atrophic gastri- tis. And provides important chnical evidence for the treatment of CAG. Methods The system retrieves the Chinese bio-medical liter- ature database, weipu, wanfang, Cochrane library, PubMed, China knowledge network, and Chinese periodical network （ data： 2000.01 to 2017. 04）, the randomized controlled trial of spleen and stomach and other treatments was studied. According to the inclusion and exclusion criteria, hterature was selected and data was extracted. The quality of the literature was evaluated and the data were extrac- ted by Jadad scoring method by 2 reviewers, The Meta analysis was performed by Rev Man5. 3 software. Results A total of 11 arti- cles were included, all Jadad scores included in the literature were 1 - 2 points, with a total of 759 patients. Meta analysis results show： The total efficiency of the treatment group was better than that of simple western medicine or TCM treatment group. The differ- ence was statistically significant [ OR = 4. 30,95% CI （2. 81,6.58）, P 〈 0. 00001 ] ;The improvement rate of gastric mirror in the ex- perimental group was better than the control group, and the difference was statistically significant [ OR = 3.36,95 % CI （1.70,6.64）, P = 0. 0005 ] ;The pathological improvement of the experimental group was better than that of the control group, and the difference was statistically significant [ OR = 3.99,95% CI （2. 47,6.46）, P 〈 0. 00001 ]. Conclusion Spleen and stomach method in the treatment of CAG in improving clinical symptoms, gastroscopy and pathological aspects of the improvement of improvement were better than the control group,and the overall effect is better than the control group. However,the quality of the literature is low,and the exact conclusions need to be confirmed by higher quality tests.