文献类型：期刊文献

中文题名：针刀治疗原发性干燥综合征口眼干燥症状疗效观察

英文题名：Observation on therapeutic effect of needle-knife for dry mouth and eyes symptoms of primary Sjogren’s syndrome

作者：张娟[1];王海东[2];杨会军[2]

第一作者：张娟

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省中医院风湿骨病科,兰州730050

第一机构：甘肃中医药大学

年份：2019

卷号：39

期号：11

起止页码：1173

中文期刊名：中国针灸

外文期刊名：Chinese Acupuncture & Moxibustion

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；PubMed;

语种：中文

中文关键词：原发性干燥综合征;针刀;口眼干燥;唾液流率;泪液流量;免疫球蛋白

外文关键词：primary Sjogren’s syndrome;needle-knife;dry mouth and eyes;salivary flow rate;tear volume;immunoglobulin

摘要：目的:比较针刀松解术与西药硫酸羟氯喹治疗原发性干燥综合征口眼干燥症状的临床疗效。方法:将60例原发性干燥综合征患者随机分为观察组和对照组,每组30例。观察组予以针刀松解术治疗(枕外隆凸左右旁开2 cm再向下2~3 cm的范围内,C2棘突左右外侧骨缘,C3、C4棘突间及左右旁开1.5~3 cm范围内,左右下颌角与乳突之间各定一点),每周1次,共8次;对照组予以口服硫酸羟氯喹,每次0.2 g,每日2次,4周为一疗程,共2个疗程。观察两组患者治疗前后唾液流率、泪液流量,血清免疫球蛋白IgG、IgA、IgM含量,以及中医证候积分的变化,并评定两组疗效。结果:观察组总有效率为86.7%(26/30),优于对照组的70.0%(21/30,P<0.05);两组患者治疗后唾液流率、泪液流量、血清IgG及中医证候积分均明显改善(均P<0.05),且改善程度观察组优于对照组(均P<0.05);血清IgA、IgM治疗前后和组间比较差异无统计学意义(均P>0.05)。结论:针刀松解术在改善原发性干燥综合征患者的口眼干燥症状、降低血清IgG含量方面优于西药硫酸羟氯喹。
Objective To compare the clinical efficacy of needle-knife and hydroxychloroquine sulfate in the treatment of dry mouth and eyes symptoms of primary Sj?gren’s syndrome. Methods A total of 60 patients with primary Sj?gren’s syndrome were randomly divided into an observation group and a control group, 30 cases in each group. In the observation group, needle-knife was used in the range of 2 cm and 2-3 cm below the occipital protuberance, the left and right lateral bone edges of the C2 spinous process, between and within the range of 1.5-3 cm beside the C3 and C4 spinous processes, points between the left and right mandibular angle and the mastoid, the treatment was given 1 time a week for 8 times. The hydroxychloroquine sulfate was applied 0.2 g each time, 2 times daily, 4 weeks as a course and a total of 2 courses in the control group. The changes of salivary flow rate, tear volume, serum immunoglobulin IgG, IgA, IgM contents and Chinese medicine symptom score were observed before and after treatment in the two groups, and the efficacy was evaluated. Results The total effective rate in the observation group was 86.7%(26/30), which was better than 70.0%(21/30) in the control group(P<0.05). The salivary flow rates, tear volume, serum IgG contents and Chinese medicine symptom scores in the two groups were significantly improved after treatment(all P<0.05), and the improvement degree in the observation group was better than the control group(all P<0.05). There was no significant difference in IgA and IgM between the two groups and before and after treatment(all P>0.05). Conclusion Needle-knife is superior to hydroxychloroquine sulfate in improving dry mouth and eyes symptoms and reducing serum IgG content in patients with primary Sj?gren’s syndrome.