文献类型：期刊文献

中文题名：静息态功能磁共振在抑郁症伴认知障碍患者中应用的研究进展

英文题名：Research Progress on Resting State Brain Function of Cognitive Impairment in Depression

作者：张琴[1];侯勇哲[1];段立刚[2];王琳[2]

第一作者：张琴

机构：[1]甘肃中医药大学第一临床医学院,兰州730030;[2]甘肃中医药大学附属医院影像科,兰州730030

第一机构：甘肃中医药大学临床医学院

年份：2023

卷号：44

期号：2

起止页码：246

中文期刊名：国际老年医学杂志

外文期刊名：International Journal of Geriatrics

收录：CSTPCD

基金：甘肃省科技计划资助项目(18JR2FA001);甘肃省教育厅重大项目(LCCX2021001)。

语种：中文

中文关键词：抑郁症;静息态功能磁共振成像;认知障碍

外文关键词：Depression;Resting state functional magnetic resonance imaging;Cognitive impairment

摘要：认知障碍(CI)是抑郁症的核心症状,主要特征为执行功能、记忆力及注意力等功能受损。抑郁症和CI存在密切联系,抑郁症会干扰认知功能,甚至可能导致假性痴呆,这也是抑郁症患者疗效不佳的因素之一。抑郁症伴CI的患者大脑存在结构和功能的改变,临床极易忽视,静息态功能磁共振成像技术可敏感地发现不同脑区的功能改变,已被广泛用于抑郁症伴CI的研究。本文概述了抑郁症伴CI患者局部脑区活动、脑功能网络连接异常和图论分析研究,为其早期诊断及治疗提供依据。
Cognitive impairment(CI)is the core symptom of depression and is characterized by impaired executive functioning,memory and attention.Depression and CI are closely linked,as well as depression can interfere cognitive function and may even lead to pseudo-dementia,which is one of the factors that make the outcome of depressed patients unsatisfactory.However,the structural and functional alterations in the brain of patients with CI in depression are easily ignored clinically.The resting state functional magnetic resonance imaging(rs-fMRI)is sensitive to detect functional alterations in different brain regions and has been widely used in the study of depression with CI.This review outlines the study of local brain area activity,abnormal brain functional network connectivity and graph theory analysis in patients with depression with CI in order to provide a solid image basis for early diagnosis and treatment.