文献类型：期刊文献

英文题名：Possible Future Avenues for Rheumatoid Arthritis Therapeutics: Hippo Pathway

作者：Wang, Tao[1,2];Wang, Zhandong[1];Qi, Wenxia[1];Jiang, Ganggang[1];Wang, Gang[2]

第一作者：王涛;王韬

通信作者：Wang, G[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730020, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730020, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730020, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2023

卷号：16

起止页码：1283

外文期刊名：JOURNAL OF INFLAMMATION RESEARCH

收录：;Scopus(收录号：2-s2.0-85152268195);WOS:【SCI-EXPANDED(收录号:WOS:000955873400001)】；

基金：Funding This work received support from the National Natural Science Foundation of China (81860858 and 81960832) , Youth Science and technology Fund of Science and Technology Department of Gansu Province (21JR11RA158) .

语种：英文

外文关键词：Hippo pathway; rheumatoid arthritis; pathogenesis; immune cell

摘要：Rheumatoid arthritis (RA) is a persistent systemic autoimmune disease with the hallmarks of swelling of the joint, joint tenderness, and progressive joint destruction, which may cause synovial inflammation and pannus as a basic pathological change, resulting in joint malformations and serious disorders. At present, the precise etiology and mechanism of pathogenesis of RA are unknown. The imbalance of immune homeostasis is the origin of RA. Hippo pathway is widely expressed in a range of cell lineages and plays a fundamental role in maintaining the immune steady state and may be involved in the pathogenic mechanism of RA. This study reviews the progress of Hippo pathway and its main members in the pathogenesis of RA from three aspects: regulating the maintenance of autoimmune homeostasis, promoting the pathogenicity of synovial fibroblasts and regulating the differentiation of osteoclasts. The study also presents a new way to recognize the pathogenesis of rheumatoid arthritis, which is favorable for finding a new way for treating the rheumatoid arthritis.