文献类型：期刊文献

中文题名：同型半胱氨酸、超敏C反应蛋白在中老年急性心肌梗死患者的相关性研究

英文题名：Correlation study of homocysteine and hypersensitive C-reactive protein in acute myocardial infarction in middle-aged and elderly population

作者：王海军[1];李德红[2];吴建军[4];高志凌[3]

第一作者：王海军

机构：[1]甘肃省人民医院核医学科,甘肃兰州730000;[2]甘肃省人民医院检验科,甘肃兰州730000;[3]甘肃省人民医院心内科,甘肃兰州730000;[4]甘肃中医药大学公共卫生学院,甘肃兰州730000

第一机构：甘肃省人民医院核医学科,甘肃兰州730000

年份：2020

卷号：46

期号：5

起止页码：44

中文期刊名：兰州大学学报：医学版

收录：CSTPCD

基金：军队医学科技青年培育计划资助项目(18QNP049)。

语种：中文

中文关键词：动脉粥样硬化;急性心肌梗死;同型半胱氨酸;超敏C反应蛋白

外文关键词：atheroselerosis;acute myocardial infarction;homocysteine;high-sensitivity C-reactive protein

摘要：目的观察中老年急性心肌梗死(AMI)患者人群同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)的水平,并探讨Hcy、hs-CRP与急性心肌梗死的相关性。方法收集甘肃省人民医院2016年1月-2017年1月确诊的AMI患者46例作为病例组,选择同期同年龄段48例健康人作为对照组。检测2组人群血清尿素(BUN)、肌酐(Cr)、尿酸(UA)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、hs-CRP、Hcy水平,并探讨上述指标与AMI之间的相关性,评价Hcy和hs-CRP的临床诊断价值。结果病例组BUN、Cr、hs-CRP、Hcy高于对照组(P<0.05),TC、TG、HDL-C、LDL-C低于对照组(P<0.05)。经二分类Logistic多因素回归分析,所有指标中仅hs-CRP和Hcy与AMI差异有统计学意义(分别为P=0.02,0.01),OR分别为1.75(95%CI[1.08,2.85])和1.52(95%CI[1.12,2.06])。Hcy和hs-CRP诊断AMI曲线下面积分别为0.84、0.90。结论Hcy和hs-CRP可能与急性心肌梗死相关,Hcy和CRP对AMI具有诊断价值。
Objective To observe the levels of homocysteine(Hcy)and high-sensitivity C-reactive protein(hs-CRP)in middle-aged and elderly patients with acute myocardial infarction(AMI),and to investigate the relationship of Hcy and hs-CRP between AMI group and the control group.Methods A total of 46 AMI patients diagnosed in Gansu Provincial Hospital from January 2016 to January 2017 were enrolled into present study,and 48 healthy persons with the same age were enrolled into the control group.The concentration of serum urea,creatinine,uric acid,total cholesterol,triglyceride,high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C),hs-CRP and Hcy were detected and the correlation between those indicators and AMI was explored.The clinical diagnostic value of Hcy and hs-CRP was evaluated.Results The contents of urea,creatinine,hs-CRP and Hcy were significantly increased in AMI group and normal control group,more than those in the control group(P<0.05).Total cholesterol,triglyceride,HDL-C and LDL-C were significantly decreased more than those in the control group(P<0.05).The abnormal rates of BMI,urea,triglyceride,hs-CRP and Hcy in AMI group were increased much more than those in the control group(P<0.05).Logistic regression indicated that only hs-CRP and Hcy were associated with AMI in all indices(P=0.02,0.01,respectively).The expected values were 1.75(95%CI:[1.08,2.85])and 1.52(95%CI:[1.12,2.06]),respectively.Besides,the area under the curve of Hcy and hs-CRP in diagnosis of AMI was 0.84 and 0.90,respectively.Conclusion Hcy and CRP are associated with the development of AMI.Hcy and CRP are of moderate value in in diagnosis of AMI.