文献类型：期刊文献

中文题名：“女贞子-墨旱莲”药对主要活性成分的网络药理学研究

英文题名：Research on main active components of″Fructus Ligustri Lucidi-Ecliptae Herba″drug pair based on network pharmacology

作者：吉秀家[1];王艳波[1];李芳[1];许瑞[1]

第一作者：吉秀家

机构：[1]甘肃中医药大学护理学院,甘肃兰州710000

第一机构：甘肃中医药大学护理学院

年份：2020

卷号：27

期号：12

起止页码：12

中文期刊名：中国当代医药

外文期刊名：China Modern Medicine

语种：中文

中文关键词：网络药理学;女贞子;墨旱莲;活性成分

外文关键词：Network pharmacology;Fructus Ligustri Lucidi;Ecliptae Herba;Active ingredient

摘要：目的运用网络药理学方法探讨“女贞子-墨旱莲”药对的主要活性成分、靶点,初步研究其药理学作用机制,为进一步深入探讨其药理学作用提供新线索。方法通过文献挖掘及检索数据库的方法筛选出“女贞子-墨旱莲”的主要活性成分、靶点,构建成分-靶点数据库,导入Cytoscape软件构建网络,获取靶点信息。筛选出关键靶点,利用metascape系统进行富集和通路分析。结果经筛选得到“女贞子-墨旱莲”有活性成分24个,共248个靶点,主要涉及体液调节、对氧反应、细胞凋亡、神经受体相互作用等生物学过程中的多条信号通路。结论网络药理学方法初步揭示了“女贞子-墨旱莲”药对的主要药理学机制。
Objective To explore the main active ingredients and targets of the″Fructus Ligustri Lucidi-Ecliptae Herba″drug pair using the network pharmacology method,so as to study the mechanism of pharmacological action,and provide a new clue for further in-depth study of its pharmacological effect.Methods By searching the TCMSP database,combined the oral bioavailability and chemochemical property analysis,the effective components and target information of limond-inkwort were screened,and Cytoscape software was used to construct the component-target network to obtain the target information.Metascape system was used to annotate and analyze gene function and pathway.Results A total of 24 candidate active molecules were screened from the″Fructus Ligustri Lucidi-Ecliptae Herba″drug pair,acting on 248 targets,mainly involving multiple signaling pathways in biological processes such as humoral regulation,oxygen response,cell apoptosis,and neural receptor interaction.Conclusion Network pharmacology method reveales the main pharmacological mechanism of″Fructus Ligustri Lucidi-Ecliptae Herba″drug pair.