文献类型：期刊文献

英文题名：Microneedle-based transdermal delivery systems for metabolic bone diseases: advances, challenges, and future perspectives

作者：Xie, Xingwen[1,2];Zheng, Xianli[1];Li, Dingpeng[3];Zhou, Qiang[1];Liu, Qiang[1];Liu, Min[1];Wang, Hui[1];Liu, Naijia[1];Zhu, Yanping[1];Zhao, Yongli[1];Gao, Yaxiong[1,2]

第一作者：Xie, Xingwen

通信作者：Gao, YX[1];Gao, YX[2]

机构：[1]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[3]Second Peoples Hosp Gansu Prov, Lanzhou, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;

年份：2026

卷号：14

外文期刊名：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

收录：;EI(收录号：20261120249821);Scopus(收录号：2-s2.0-105032385836);WOS:【SCI-EXPANDED(收录号:WOS:001710495700001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the National Natural Science Foundation of China (Nos. 82374491, 82160911), Major Science and Technology Project of Gansu Province (No. 22ZD6FA021), Gansu Provincial University Industry Support Plan Project (No. 2023CYZC-57), Gansu Provincial Youth Science and Technology Fund Program (No. 2020-0406-JCC-0452), Gansu Provincial Science and Technology Plan Project (Nos.20JR5RA129, 25JRRA836), Open Research Projects of Gansu Provincial Research Center for Traditional Chinese Medicine (No.zyzx-2020-32), Project guided by Lanzhou Municipal Bureau of Science and Technology (No. 2022-ZD-53), Lanzhou Science and Technology Plan Project (No. 2025-5-134). At the same time, we also appreciate the support of the 2025 Clinical Key Specialty Capability Enhancement Project (Geriatric Orthopedics) and the National Traditional Chinese Medicine Advantage Specialty (Orthopedics).

语种：英文

外文关键词：bone-targeted nanocarriers; intelligent closed-loop delivery; metabolic bone diseases; microneedles; transdermal drug delivery

摘要：Metabolic bone diseases (MBDs), such as osteoporosis and rickets, present significant clinical challenges due to the chronic nature of treatment and the limitations of conventional systemic therapies. Oral medications often suffer from low bioavailability and gastrointestinal intolerance, while injectable biologics are hampered by poor patient adherence. Microneedle (MN) systems have emerged as a transformative transdermal delivery platform capable of overcoming these barriers. This review provides a comprehensive overview of MN technology, detailing its classification, material properties, and advantages in bypassing the stratum corneum for painless administration. We analyze how MNs have evolved from physical conduits into intelligent therapeutic platforms that integrate bone-targeting ligands, stimuli-responsive release mechanisms, and immunomodulatory functions to precisely regulate the bone microenvironment. Furthermore, we summarize recent preclinical advances in MN applications for MBDs, highlighting their ability to improve pharmacokinetic profiles and therapeutic efficacy. Finally, the review critically examines current hurdles regarding manufacturing, safety, and clinical translation, and offers perspectives on next-generation systems that combine diagnostic sensing with adaptive therapy to realize personalized bone health management.