文献类型：期刊文献

英文题名：Knockdown of LOX-1 ameliorates bone quality and generation of type H blood vessels in diabetic mice

作者：Qiu, Jumei[1,2];Liu, Jing[2,3];Tian, Limin[1,2,3];Yu, Jing[2,3];Duan, Qidang[1,2];Liu, Yaqian[1,2];Zhao, Wenshu[1,2];Si, Huiling[1,2];Lu, Xun[4];Zhang, Qi[1,2,3]

第一作者：Qiu, Jumei

通信作者：Zhang, Q[1]

机构：[1]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Geriatr, Lanzhou 730000, Gansu, Peoples R China;[3]Clin Res Ctr Metab Dis, Lanzhou 730000, Gansu, Peoples R China;[4]Ningxia Med Univ, Yinchuan 750000, Ningxia Hui Aut, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：752

外文期刊名：ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

收录：;Scopus(收录号：2-s2.0-85181801556);WOS:【SCI-EXPANDED(收录号:WOS:001154303700001)】；

基金：This study was funded by the National Natural Science Foundation of China (grant numbers 81960173 and 82160166) , Lanzhou Talents Innovation and Entrepreneurship Project (2021-RC-136) , Sweet Medicine Doctor Project (2021SD01) , and Provincial Youth Science and Technology Fund Program (21JR1RA008) .

语种：英文

外文关键词：LOX-1; BMP2; Tracp5b; Type H blood vessel; Bone quality; Diabetic osteoporosis

摘要：Our previous studies have shown that lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) is expressed in liver sinusoidal endothelial cells, and oxidized low-density lipoprotein induces liver sinusoidal dysfunction and defenestration through the LOX-1/ROS/NF-kB pathway, revealing that LOX-1 can mediate liver sinusoidal barrier function, involved in the regulation of non-alcoholic fatty liver disease. Here, we investigated whether, in the context of bone metabolic diseases, LOX-1 could affect bone quality and type H blood vessels in diabetic mice. We used db/db mice as model and found that LOX-1 knockdown can ameliorate bone quality and type H blood vessel generation in db/db mice. This further verifies our hypothesis that LOX-1 is involved in the regulation of bone quality and type H blood vessel homeostasis, thus inhibiting osteoporosis progression in db/db mice.