文献类型：期刊文献

中文题名：肌骨共生相关信号通路研究进展

英文题名：Research Progress on Emerging Signaling Pathways Related to Muscle Bone Symbiosis

作者：刘晏东[1];邓强[2];张彦军[2];李中锋[2];彭冉东[2];郭铁峰[2];王雨榕[2];陈博[1]

第一作者：刘晏东

机构：[1]甘肃中医药大学,兰州730030;[2]甘肃省中医院,兰州730050

第一机构：甘肃中医药大学

年份：2024

卷号：15

期号：1

起止页码：147

中文期刊名：协和医学杂志

外文期刊名：Medical Journal of Peking Union Medical College Hospital

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家中医药管理局国家中医临床研究基地业务建设科研专项(JDZX2015039);甘肃省联合基金(23JRRA1534);兰州市科技计划(2022-3-30)。

语种：中文

中文关键词：成肌;成骨;信号通路;肌少-骨质疏松症

外文关键词：myoblast;osteogenesis;signal pathway;osteosarcopenia

摘要：骨质疏松症是一种以骨量降低、骨组织微结构损坏、骨脆性增加、易发生骨折为特征的全身代谢性骨病,而肌少症是以进行性全身肌量减少和功能减退为主要特征的综合征。基于二者共同的病理生理机制及密切相关性,逐渐衍生出“肌少-骨质疏松症”这一概念,以描述肌肉与骨骼同时发生衰减的现象。信号通路作为肌肉与骨骼之间重要的信号传递途径,如发生异常,则会导致肌少-骨质疏松症的发生。因此,本文就Hedgehog、Hippo、mTOR和MAPK等成骨与成肌相关信号通路进行综述,以期为肌少-骨质疏松症的靶向治疗提供新思路。
Osteoporosis is a systemic metabolic bone disease characterized by decreased bone mass,damage to bone tissue microstructure,increased bone fragility,and susceptibility to fractures,while sarcopenia is a syndrome characterized by progressive reduction in overall muscle mass and functional decline.Based on the common pathophysiological mechanism and close correlation between the two,the concept of“osteosarcopenia”has gradually emerged to describe the simultaneous attenuation of muscles and bones.Signaling pathways serve as important signal transmission channels between muscles and bones,and if abnormal,they can lead to osteosarcopenia.The aim of this article,therefore,is to review the signaling pathways related to osteogenesis and myogenesis,such as Hedgehog,Hippo,mTOR,MAPK,in order to provide new ideas for targeted treatment of osteosarcopenia.