文献类型：期刊文献

中文题名：SOX序贯化疗联合替吉奥同步放疗治疗胃癌术后腹腔淋巴结转移疗效观察

英文题名：Observation of Efficacy and Safety of SOX Regimen Sequential Chemotherapy Combined with Tegafur Gimeracil Oteracil Potassium Capsule and Radiation in Treating Abdominal Lymphatic Metastases after Gastric Cancer Operation

作者：高琳[1];潘杰[1];宋鹏[2];潘东风[1];汪彬彬[1]

第一作者：高琳

机构：[1]湖北医药学院附属随州医院,湖北随州441300;[2]甘肃中医药大学附属医院

第一机构：湖北医药学院附属随州医院,湖北随州441300

年份：2020

卷号：29

期号：11

起止页码：736

中文期刊名：药物流行病学杂志

外文期刊名：Chinese Journal of Pharmacoepidemiology

收录：CSTPCD

语种：中文

中文关键词：胃癌;腹腔淋巴结转移;SOX方案化疗;区域调强适形放射治疗;替吉奥;疗效;安全性

外文关键词：Gastric cancer;Abdominal lymphatic metastases;SOX regimen chemotherapy;Regional intensity modulated conformal radiotherapy;Tegafur gimeracil oteracil potassium capsule;Efficacy;Safety

摘要：目的:观察SOX序贯化疗联合替吉奥同步放疗治疗胃癌术后腹腔淋巴结转移的临床疗效与不良反应。方法:胃癌术后发生腹腔淋巴结转移的患者62例按入院先后顺序分为观察组32例与对照组30例。观察组采用SOX方案化疗2周期后,行肿瘤累及区域调强适形放射治疗(IMRT),放疗同时给予同步口服替吉奥,放化疗结束后继续给予SOX方案化疗4周期;对照组给予SOX方案化疗6周期。治疗结束后1个月对比两组患者的治疗效果、生活质量及不良反应发生情况。结果:观察组的近期总有效率、疾病控制率均明显高于对照组(P<0.05),中位OS时间、1年生存率也高于对照组(P<0.05)。治疗后,两组患者的KPS评分均较前明显升高(P<0.05),且观察组的KPS评分和生活质量良好率均明显高于对照组(P<0.05)。两组患者Ⅰ~Ⅳ度不良反应发生率差异无统计学意义(P>0.05),治疗期间均未出现化疗相关性死亡。结论:SOX序贯化疗联合替吉奥同步放疗治疗胃癌术后腹腔淋巴结转移,与单纯化疗比较,提高了治疗效果与患者生活质量,且未增加不良反应,为胃癌术后腹腔淋巴结转移患者提供了较好的治疗方案。
Objective:To observe the efficacy and adverse drug reaction of SOX regimen sequential chemotherapy combined with tegafur gimeracil oteracil potassium capsule(S-1)and radiation in treating abdominal lymphatic metastases after gastric cancer operation.Methods:Totally 62 patients with abdominal lymphatic metastases after gastric cancer operation were divided into observation group(32 cases)and control group(30 cases)according to the order of admission.The observation group was treated with SOX regimen chemotherapy 2 cycles first,then S-1 combined with intensity-modulated radiation therapy(IMRT)at the same time,at last followed the same chemotherapy by 4 cycles.The control group received SOX regimen chemotherapy alone 6 cycles.The clinical efficacy,quality of life,adverse drug reaction of two groups were compared one month after treatment.Results:The total effective rate and tumor control rate in the observation group were higher than the control group(P<0.05).The median OS time in the observation group was longer than the control group,the 1-year survival rate in the observation group was higher than the control group(P<0.05).After treatment,KPS scores of both groups were significantly higher than before(P<0.05),and KPS scores and good quality of life rates of the observation group were significantly higher than those of the control group(P<0.05).There was no significant difference of incidence of adverse reactions inⅠtoⅣbetween the two groups(P>0.05).And all patients during the treatment did not appear chemotherapy-related deaths.Conclusion:SOX regimen sequential chemotherapy combined with S-1 and radiation in treating abdominal lymphatic metastases after gastric cancer operation,compared with SOX regimen chemotherapy alone,it could improve the treatment effect and quality of life of patients without obvious increment of adverse reaction.It provided a better treatment plan for patients with abdominal lymph node metastasis after gastric cancer surgery.