文献类型：期刊文献

英文题名：Natural products protect against spinal cord injury by inhibiting ferroptosis: a literature review

作者：She, Wei[1,2];Su, Junxiao[2];Ma, Wenji[3];Ma, Guohai[1];Li, Jianfu[2];Zhang, Hui[2];Qiu, Cheng[4,5];Li, Xingyong[1,2]

第一作者：She, Wei

通信作者：Li, XY[1];Li, XY[2];Qiu, C[3];Qiu, C[4]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Orthopaed Surg, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Univ, Hosp 1, Dept Orthopaed Surg, Lanzhou, Gansu, Peoples R China;[4]Shandong Univ, Qilu Hosp, Dept Orthopaed Surg, Jinan, Shandong, Peoples R China;[5]Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Orthopaed Surg, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Shandong Univ, Qilu Hosp, Dept Orthopaed Surg, Jinan, Shandong, Peoples R China;[4]corresponding author), Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105002631879);WOS:【SCI-EXPANDED(收录号:WOS:001468471800001)】；

语种：英文

外文关键词：spinal cord injury; ferroptosis; natural product; GPx4; ROS

摘要：Spinal cord injury (SCI) is a severe traumatic condition that frequently results in various neurological disabilities, including significant sensory, motor, and autonomic dysfunctions. Ferroptosis, a recently identified non-apoptotic form of cell death, is characterized by the accumulation of reactive oxygen species (ROS), intracellular iron overload, and lipid peroxidation, ultimately culminating in cell death. Recent studies have demonstrated that ferroptosis plays a critical role in the pathophysiology of SCI, contributing significantly to neural cell demise. Three key cellular enzymatic antioxidants such as glutathione peroxidase 4 (GPX4), ferroptosis suppressor protein 1 (FSP1), and dihydroorotate dehydrogenase (DHODH), have been elucidated as crucial components in the defense against ferroptosis. Natural products, which are bioactive compounds mostly derived from plants, have garnered considerable attention for their potential therapeutic effects. Numerous studies have reported that several natural products can effectively mitigate neural cell death and alleviate SCI symptoms. This review summarizes fifteen natural products containing (-)-Epigallocatechin-3-gallate (EGCG), Proanthocyanidin, Carnosic acid, Astragaloside IV, Trehalose, 8-gingerol, Quercetin, Resveratrol, Albiflorin, Alpha-tocopherol, Celastrol, Hispolon, Dendrobium Nobile Polysaccharide, Silibinin, and Tetramethylpyrazine that have shown promise in treating SCI by inhibiting ferroptosis. Additionally, this review provides an overview of the mechanisms involved in these studies and proposes several perspectives to guide future research directions.