文献类型：期刊文献

英文题名：Decoding the educational impact on Alzheimer's risk: an umbrella review of Mendelian randomization evidence

作者：Xu, Jianguo[1,2,3];Zhang, Xiaobiao[1,4];Cui, Yating[1,2];Zheng, Qingyong[1,2,5];Wang, Caixia[6,7];Kang, Yingying[2];Xing, Lina[2];Zhang, Xin[8];Qin, Yu[9];Yuan, Kaisen[2];Huang, Ling[2];Tian, Jinhui[1,2,10]

第一作者：Xu, Jianguo

通信作者：Tian, JH[1];Tian, JH[2];Tian, JH[3]

机构：[1]Lanzhou Univ, Evidence Based Med Ctr, Lanzhou, Peoples R China;[2]Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Peoples R China;[3]Populat Hlth Res Inst, Hamilton, ON, Canada;[4]Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Ctr Vasc Surg, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China;[5]McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada;[6]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[7]Gansu Hlth Vocat Coll, Sch Tradit Chinese Med, Lanzhou, Peoples R China;[8]Gansu Hlth Vocat Coll, Sch Pharm, Lanzhou, Peoples R China;[9]Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China;[10]Key Lab Evidence Based Med Gansu Prov, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Evidence Based Med Ctr, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou, Peoples R China;[2]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Peoples R China;[3]corresponding author), Key Lab Evidence Based Med Gansu Prov, Lanzhou, Peoples R China.

年份：2026

外文期刊名：AGING & MENTAL HEALTH

收录：;Scopus(收录号：2-s2.0-105031523001);WOS:【SSCI(收录号:WOS:001704353200001)，SCI-EXPANDED(收录号:WOS:001704353200001)】；

基金：This work was supported by the Innovation Fund Project for Higher Education Teachers of Gansu Provincial Department of Education (2024B-322), the Higher Education Teaching Achievement Cultivation Project of Gansu Province (202318), and the Team Construction Project for the School of Basic Medical Sciences, Lanzhou University (jchj202301).

语种：英文

外文关键词：Educational attainment; Alzheimer's disease; cognitive traits; mendelian randomization; umbrella review

摘要：Objectives: Alzheimer's disease (AD) remains a major global health challenge. The objective of this umbrella review is to synthesize Mendelian Randomization (MR) evidence evaluating the causal relationship between educational attainment (EA) and AD risk, thereby addressing the inherent limitations of observational studies. Methods: We conducted a comprehensive literature search in PubMed, Embase, and Web of Science up to July 6, 2023. MR studies investigating the causal relationship between EA and AD risk were included. We assessed study quality using the STROBE-MR checklist and graded evidence strength. Due to heterogeneity in genetic instruments, a qualitative synthesis was performed. Results: Eleven publications examining 41 distinct associations were included. Most studies reported a consistent protective effect of EA on AD risk. However, this protective effect was attenuated when mediated by cognitive traits, which independently protected against AD. Quality assessment revealed variability in adherence to reporting guidelines, notably concerning study pre-registration and broad generalizability. Conclusion: Findings highlight a complex interplay between EA, cognitive traits, and AD risk, aligning with the cognitive reserve hypothesis. Ultimately, EA exhibits a protective effect against AD, largely mediated by cognitive traits, and likely explained by multiple structural and lifestyle mechanisms. Future research must prioritize longitudinal designs and gene-environment interactions.