文献类型：期刊文献

中文题名：硫化氢在H型高血压中的研究进展

英文题名：Research progress of hydrogen sulfide in H-type hypertension

作者：沈路凡[1];王鸿[1];吕红英[1];贾冠军[1];侯明双[1];伊琳[1]

第一作者：沈路凡

机构：[1]甘肃中医药大学中西医结合学院,甘肃省中医药防治慢性疾病重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2024

卷号：40

期号：9

起止页码：1601

中文期刊名：中国药理学通报

外文期刊名：Chinese Pharmacological Bulletin

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金资助项目(No 82160842);联合科研基金一般项目(No 23JRRA1521);甘肃省“双一流”科研重点项目(No GSSYLXM-01)。

语种：中文

中文关键词：硫化氢;H型高血压;同型半胱氨酸;血管舒张;作用机制;综述

外文关键词：hydrogen sulfide;H-type hypertension;homocysteine;vasodilation;mechanism of action;review

摘要：硫化氢(hydrogen sulfide,H_(2)S)是一种参与血管张力调节的内源性气体传递素,具有多种生理特性,如抗高血压、血管松弛、抗炎和抗氧化潜能,在心血管调节中发挥重要作用。同型半胱氨酸(homocysteine,HCY)与心血管疾病的发生、发展密切相关。高同型半胱氨酸血症(HCY≥10μmol·L^(-1))是冠状动脉粥样硬化性心脏病、脑卒中等心脑血管疾病的危险因素,中国学者将伴有高同型半胱氨酸血症的原发性高血压定义为H型高血压,约占我国成年高血压患者的75%。H型高血压的治疗应同时降低血压和血浆HCY的水平。研究表明,H_(2)S能够拮抗高血压和高HCY,提示H_(2)S可能成为H型高血压的潜在治疗靶点。因此,该文就H_(2)S对高血压和HCY的作用机制进行总结。
Hydrogen sulfide(H_(2)S),an endogenous gas transmitter involved in the regulation of vascular tone,has a variety of physiological properties,such as antihypertensive,vascular relaxation,anti-inflammatory and antioxidant potential,and plays an important role in cardiovascular regulation.Chinese scholars call essential hypertension combined with hyperhomocysteinemia(HCY≥10μmol·L^(-1))as H-type hypertension.Studies have shown that H_(2)Scan antagonized hypertension and hyperhomocysteinemia,suggesting that H_(2)Smay be a potential therapeutic target for H-type hypertension.Therefore,this article briefly summarizes the mechanism of H_(2)Son hypertension and homocysteine.Homocysteine(HCY)is closely related to the occurrence and development of cardiovascular diseases.Hyperhomocysteinemia(HCY≥10μmol·L^(-1))is a risk factor for coronary atherosclerotic heart disease,stroke,and other cardiovascular diseases,and Chinese scholars define primary hypertension accompanied by hyperhomocysteinemia as H-type hypertension,which accounts for about 75%of the adult hypertensive patients in China.The treatment of H-type hypertension should simultaneously reduce blood pressure and plasma HCY levels.Studies have shown that hydrogen sulfide(H_(2)S)can antagonise hypertension and high HCY,suggesting that H_(2)Smay be a potential therapeutic target for H-type hypertension.Therefore,this paper summarizes the mechanism of action of H_(2)Son hypertension and HCY.