文献类型：期刊文献

中文题名：酪氨酸蛋白激酶6在肿瘤发生与发展中的研究进展

英文题名：Progress in the study of tyrosine protein kinase 6 in tumorigenesis and development

作者：赵川[1];王秀月[1];陈彻[1]

第一作者：赵川

机构：[1]甘肃中医药大学临床医学院临床检验诊断学分子生物实验室,甘肃兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2017

卷号：37

期号：3

起止页码：302

中文期刊名：肿瘤

外文期刊名：Tumor

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD2017_2018】；

基金：国家自然科学基金资助项目(编号:81460456);甘肃省自然科学基金资助项目(编号:1308RJZA169)~~

语种：中文

中文关键词：肿瘤;蛋白酪氨酸激酶类;信号转导;预后

外文关键词：Neoplasms; Protein-tyrosine kinases; Signal transduction; Prognosis

摘要：酪氨酸蛋白激酶6(protein tyrosine kinase 6,PTK6)是一种存在于细胞内的非受体蛋白激酶,最早是在对小肠上皮细胞分化的相关研究中被发现的,主要生理功能是促进正常上皮细胞的分化。然而,近些年来的研究表明,PTK6在许多肿瘤中都有表达,在肿瘤的发生与发展中扮演着重要的角色,与其相关的信号分子一起影响着肿瘤细胞的增殖、迁移、侵袭与转移等。PTK6作为肿瘤治疗的新靶点现已引起了研究人员的广泛关注。因此,本文将就PTK6及其相关信号分子表达对肿瘤发生、发展及预后影响的研究进展进行综述。
Protein tyrosine kinase 6 （PTK6） is a cytoplasmic non-receptor protein kinase. PTK6 was found in the study on the differentiation of small intestinal epithelial cells, and its main physiological function is to promote the differentiation of normal epithelial cells. However, recent studies have showed that PTK6 is expressed in many tumors, plays an important role in the occurrence and development of tumor, and it is associated with its related signaling molecules to affect the proliferation, migration, invasion and metastasis of tumor cells. As a new target of tumor therapy, PTK6 has attracted extensive attention of researchers. Therefore, this article summarizes the research progress in the effects of PTK6 and its related signaling molecules on the occurrence, development and prognosis of tumor.