文献类型：期刊文献

英文题名：Hemostatic effects of FmocF-ADP hydrogel consisted of Fmoc-Phenylalanine and ADP

作者：Qin, Tiansheng[1];Huang, Xiande[1];Zhang, Qianqian[1];Chen, Fan[1];Zhu, Jiaojiao[1];Ding, Yaoyao[1]

第一作者：Qin, Tiansheng

通信作者：Qin, TS[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, West Donggang Rd 204, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, West Donggang Rd 204, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：55

期号：4

起止页码：499

外文期刊名：AMINO ACIDS

收录：;Scopus(收录号：2-s2.0-85147005716);WOS:【SCI-EXPANDED(收录号:WOS:000921775900002)】；

基金：This work was supported by the grant of Excellent Training Project of Gansu Provincial Hospital (19SYPYB-21), Innovation and Entrepreneurship Talent Project of Lanzhou (2020-RC-52), Natural Science Foundation of Gansu Province (Grant No. 21JR1RA012).

语种：英文

外文关键词：Bleeding; Hemostasis; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-phenyl-L-alanine (FmocF); Adenosine diphosphate (ADP); FmocF-ADP hydrogel

摘要：During trauma and surgery, bleeding is a major concern. One of the crucial strategies for hemostasis is the use of biological hemostatic material. Herein, we reported an amino acid-based hydrogel FmocF-ADP hydrogel, which consisted of N-[(9H-fluoren-9-ylmethoxy) carbonyl]-3-phenyl-L-alanine (FmocF) and adenosine diphosphate (ADP) sodium solution. The hydrogel was created by FmocF self-assembling to nanofiber in ADP sodium solution and then cross-linking to hydrogel. FmocF-ADP hydrogel showed good in vitro coagulation activity as measured by whole blood clotting assays, platelet clotting assays, platelet activation assays, and platelet adhesion assays. Further, it was noted to reveal an exceptional in vivo hemostatic effect in a mouse liver bleeding model. Together with the previous report of the good biocompatibility and antimicrobial activity of FmocF hydrogel, our study would extend the biomedical application of FmocF hydrogel. In conclusion, the present study would provide a constructive strategy for the development of new antimicrobial and hemostatic materials or develop a potential hemostatic material.