文献类型：期刊文献

中文题名：肠道病毒71感染的免疫逃逸机制研究进展

英文题名：Research progress on immune escape mechanisms of enterovirus 71 infection

作者：郭堃[1];田文霞[1];陈静[1];李玉霞[1]

第一作者：郭堃

机构：[1]甘肃中医药大学附属医院儿科,兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2026

卷号：42

期号：3

起止页码：534

中文期刊名：中国免疫学杂志

外文期刊名：Chinese Journal of Immunology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金(82160921)。

语种：中文

中文关键词：EV71;结构蛋白;抗体;免疫逃逸;综述

外文关键词：EV71;Structural proteins;Antibodies;Immune evasion;Review

摘要：肠道病毒71(EV71)是一种阳性单链RNA病毒,会造成手足口病、幼儿神经系统损伤等严重疾病。EV71感染宿主的过程是病毒与宿主免疫系统相互作用的过程,但是EV71通过干预多种宿主免疫信号通路逃避免疫攻击,从而促进其生存和复制。本文简述了EV71通过与宿主细胞表面受体结合感染宿主的过程,并指出其结构蛋白和非结构蛋白在病毒入侵及后续免疫逃逸中的关键作用。重点论述了EV71的免疫逃逸机制,包括抑制先天免疫信号通路、逃逸适应性免疫应答、调控宿主细胞凋亡与自噬及干扰补体系统等。深入了解EV71的感染机制与免疫逃逸策略,有助于揭示病毒致病的分子基础,也为研发更有效的抗病毒药物和疫苗提供理论依据。
Enterovirus 71(EV71)is a positive-sense single-stranded RNA virus responsible for severe diseases such as hand,foot,and mouth disease and neurological damage in young children.The process of EV71 infection involves intricate interactions between the virus and the host immune system.Crucially,EV71 evades immune attack by interfering with multiple host immune signaling pathways,thereby promoting its survival and replication.This article begins with a brief description of the EV71 infection process,initiated by binding to host cell surface receptors.It highlights the pivotal roles played by both its structural and non-structural proteins in viral entry and subsequent immune evasion.The review focuses in detail on the mechanisms employed by EV71 to evade host immunity.These mechanisms include:Inhibition of innate immune signaling pathways,evasion of adaptive immune responses,modulation of host cell apoptosis and autophagy and interference with the complement system.A deeper understanding of EV71's infection mechanisms and immune evasion strategies is essential for elucidating the molecular basis of its pathogenesis.Furthermore,this knowledge provides a critical theoretical foundation for developing more effective antiviral therapeutics and vaccines.