文献类型：期刊文献

中文题名：板蓝根颗粒防潮辅料的筛选

英文题名：Screening of damp-proofing excipients for Banlangen Keli

作者：朱晓玉[1];刘雄[1];宋开蓉[1];师婷婷[1];陈晖[2];高建德[1]

第一作者：朱晓玉

机构：[1]甘肃中医药大学药学院,甘肃兰州730000;[2]甘肃中医药大学教学实验中心,甘肃兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2017

卷号：34

期号：2

起止页码：58

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

语种：中文

中文关键词：板蓝根颗粒;吸湿性;数学模型;防潮辅料;筛选

外文关键词：Banlangen Keli ; hygroscopicity ; mathematical model ; damp-proofing excipients ; screening

摘要：目的优选板蓝根颗粒的最佳防潮辅料,并选出与吸湿数据拟合后相关性最高的数学模型。方法以板蓝根稠浸膏为模型药物,以吸湿性、成型性、外观变化和溶化性为考察指标,药辅比为1.0∶1.5制粒考察单一辅料对颗粒吸湿性的影响,筛选出最佳防潮辅料,并测定临界相对湿度;对吸湿数据进行数学模型拟合,比较R^2的大小,确定最佳吸湿数学模型。结果单一辅料以药物∶微晶纤维素(1.0∶1.5)的防潮效果最好,并测得其临界相对湿度为80%;3种模型中R^2值最高的是二次曲线方程,R^2≥0.97,接近0.99。结论筛选出的辅料能有效降低板蓝根颗粒的吸湿性,可用于工业化生产。
Objective To optimize the best damp-proofing excipients for Banlangen Keli, and also select the mathematical model with the highest correlation after fitting of moisture absorption data. Methods Banlangen Choujingao was used as model drug. Based on the evaluation indicators of hygroscopicity, formability, appearance change and dissolubility, the effect on hygroscopicity of single excipient was observed when the main-adjuvant for- mula was set at 1.0 ： 1.5, then screened the best excipents and measured the critical relative moisture. After mois- ture absorption data fitting, the R2 values were compared to determine the best moisture absorption mathematical model. Results The main-adjuvant formula of 1.0 ： 1.5 （ main to microcrystalline cellulose） got the best hygro- scopic effect. The critical relative moisture was 80%. The highest R2 value was in the quadratic curve equation among 3 models （R2 ≥0.97, closing to 0.99）. Conclusion The screened excipient is effective in reducing hygro- scopicity of Banlangen Keli,which can be applied to commercial production.