文献类型：期刊文献

英文题名：Zhengganxifeng Decoction Affects Gut Microbiota and Reduces Blood Pressure via Renin-Angiotensin System

作者：Yu, Xiaoying[1,2];Zhang, Xindi[2];Jin, Hua[1];Wu, Zhiwei[1];Yan, Chunlu[1];Liu, Zhijun[3];Xu, Xinghua[1];Liu, Shuangfang[1];Zhu, Feifei[1]

第一作者：Yu, Xiaoying

通信作者：Jin, H[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Petrochem Gen Hosp, Gansu Gem Flower Hosp, Lanzhou 730060, Gansu, Peoples R China;[3]Gansu Tradit Chinese Med Univ, Affiliated Hosp, Lanzhou 730020, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2019

卷号：42

期号：9

起止页码：1482

外文期刊名：BIOLOGICAL & PHARMACEUTICAL BULLETIN

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000484107100007)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 81560716, 81860832).

语种：英文

外文关键词：Zhengganxifeng decoction; spontaneously hypertensive rat; blood pressure; gut microbial composition

摘要：Zhengganxifeng decoction (ZGXFD) is a traditional Chinese medicinal formula, from "Medical Zhong parameter West recorded" by Xichun Zhang, which has been applied to the treatment of clinical essential hypertension. Besides its effect in blood pressure reduction, ZGXFD is also known to be a radical therapy with little or no side effects. Compared with western medicines, Chinese medicinal formulas have the advantage of simultaneously attacking multiple targets. However, such a property brings trouble to the pharmacological studies of Chinese medicines. This study investigated the composition of gut microbiota in spontaneously hypertensive rats (SHR) treated with ZGXFD. ZGXFD was shown to cause similar effects in the treatment group as benazepril: both were able to reduce in SHR the microbial diversity, Firmicutes to Bacteroidetes (F/B) ratio and coccus to bacillus (C/B) ratio. Meanwhile, ZGXFD can maintain the integrity of intestinal mechanistic barrier and elevate the percentage of bacteria producing short chain fatty acids (SCFA). By investigating renin angiotensin system (RAS) system, we found that ZGXFD can decrease the expression of angiotensin-converting-enzyme (ACE) in lungs, which in turn causes a increase in AngI produces angiotensin1-7 (Ang1-7) and decrease in AngII. ZGXFD regulate blood pressure in SHR via RAS.