文献类型：期刊文献

中文题名：丹栀逍遥散加减治疗纤维肌痛综合征20例临床观察

英文题名：Clinical observation on 20 cases of fibromyalgia syndrome treated by modified Danzhi Xiaoyao San(丹栀逍遥散)

作者：张娟[1];王海东[2]

第一作者：张娟

机构：[1]甘肃中医药大学中医临床学院;[2]甘肃省中医院风湿骨病科

第一机构：甘肃中医药大学中医临床学院

年份：2019

卷号：0

期号：1

起止页码：43

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

语种：中文

中文关键词：纤维肌痛综合征;丹栀逍遥散加减;盐酸曲马多缓释片;阿米替林;中医证候积分;视觉模拟评分法评分;临床疗效

外文关键词：fibromyalgia syndrome;modified Danzhi Xiaoyao San(丹栀逍遥散);tramadol hydrochloride sustained release tablets;amitriptyline hydrochloride;TCM symptom scores;visual analogue scale(VAS)scores;clinical efficacy

摘要：目的观察丹栀逍遥散加减治疗纤维肌痛综合征的临床疗效。方法将40例纤维肌痛综合征患者采用随机数字表法分为治疗组和对照组,各20例。治疗组予丹栀逍遥散加减口服,对照组予盐酸曲马多缓释片及盐酸阿米替林口服,2组均治疗4周,治疗后随访4周。比较2组的近期疗效、远期疗效及治疗前后的中医证候积分、视觉模拟评分法(VAS)评分。结果治疗4周后,治疗组总有效率为95%,对照组为80%,2组比较差异无统计学意义(P>0.05);随访4周后,治疗组总有效率为80%,对照组为30%,2组比较差异有统计学意义(P<0.05)。治疗4周后,2组VAS评分均明显降低,与同组治疗前比较差异均有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05);随访4周后,治疗组VAS评分明显低于对照组,2组比较差异有统计学意义(P<0.05)。治疗4周后及随访4周后,2组各项中医证候积分及总积分均明显降低,与同组治疗前比较差异有统计学意义(P<0.05),且治疗组降低程度更显著,组间比较差异均有统计学意义(P<0.05)。结论丹栀逍遥散加减治疗纤维肌痛综合征疗效显著,能明显改善患者的临床症状,值得临床推广运用。
Objective To observe the clinical efficacy of modified Danzhi Xiaoyao San(丹栀逍遥散) in the treatment of fibromyalgia syndrome.Methods Forty cases of fibromyalgia syndrome were divided into treatment group and control group according to random number table,with 20 cases in each.The treatment group was given oral modified Danzhi Xiaoyao San,while the control group was given oral tramadol hydrochloride sustained release tablets and amitriptyline hydrochloride.Both groups were treated for 4 weeks and followed up for 4 weeks after treatment.The short-term and long-term effects,TCM symptom scores and visual analogue scale(VAS) scores of the 2 groups before and after treatment were compared.Results After treatment for 4 weeks,the total effective rate of the treatment group was 95%,that of the control group was 80%,there was no statistically significant difference between the two groups(P>0.05).Followed up for 4 weeks,the total effective rate of the treatment group was 80%,that of the control group was 30%,there was statistically significant difference between the two groups(P<0.05).After treatment for 4 weeks,the VAS scores of the two groups both decreased significantly,there was statistically significant difference compared with the same group before treatment(P<0.05),but there was no statistically significant difference between the two groups(P>0.05).Followed up for 4 weeks,the VAS scores of the treatment group were significantly lower than those of the control group,there were statistically significant differences between the two groups(P<0.05).Four weeks after treatment and after 4 weeks of follow-up,all TCM symptom scores and the total score of the two groups both decreased significantly,there were statistically significant differences compared with the same group before treatment(P < 0.05),moreover,those decreased more significantly in the treatment group,there were statistically significant differences between the two groups(P<0.05).Conclusion It has significant curative effects to use modified Danzhi Xiaoyao San in the treatment of fibromyalgia syndrome.It can significantly improve the clinical symptoms of the patients,which deserves clinical promotion and application.