文献类型：期刊文献

中文题名：Wnt信号通路与心肌纤维化的研究进展和应用前景

英文题名：Progress and potential directions of Wnt signaling in cardiac fbrosis

作者：李娇[1];赵信科[2];魏惠平[3];刘斌[1];王志鹏[4];李应东[2]

第一作者：李娇

机构：[1]甘肃中医药大学中西医结合学院;[2]甘肃中医药大学附属医院心血管科;[3]甘肃中医药大学重症医学科;[4]甘肃中医药大学中医临床学院

第一机构：甘肃中医药大学中西医结合学院

年份：2017

卷号：33

期号：18

起止页码：1828

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2017_2018】；

基金：甘肃省自然科学基金资助项目(1508RJZA015)

语种：中文

中文关键词：心肌纤维化;抑制剂;治疗靶点

外文关键词：cardiac fibrosis; inhibitor; therapeutic target

摘要：心肌纤维化(MF)是多种心脏疾病发展到一定阶段的共同病理改变,是心肌重构的主要表现之一。这种病理变化存在于多种心血管疾病中,与心律失常、心力衰竭等疾病密切相关。Wnt信号通路具有调控细胞生长、自噬、增殖和凋亡等生物学功能。Wnt可以调控心肌成纤维化细胞(CFS)的激活和细胞外基质(ECM)的沉积,在心肌纤维化(MF)的发生发展过程中起着重要作用。Wnt信号通路抑制剂通过拮抗Wnt信号通路的异常激活从而抑制CFs激活和ECM的沉积,这提示调控Wnt通路信号传导可能成为潜在的MF治疗靶点。本文主要对Wnt信号通路与心肌纤维化作一综述,为临床治疗提供新的研究方向。
Myocardial fibrosis（ MF） is a common pathologic change in the development of a variety of heart diseases to a certain stage and is one of the major manifestations of myocardial remodeling. This pathological changes exist in a variety of cardiovascular diseases,and arrhythmia,heart failure and other diseases are closely related. Wnt signaling pathway has the biological function of regulating cell growth,autophagy,proliferation and apoptosis. Wnt can regulate the activation of cardiac fibroblasts（ CFS） and the deposition of extracellular matrix（ ECM）,which plays an important role in the development of myocardium fibrosis（ MF）.The Wnt signaling pathway suppresses CFS activation and ECM deposition by antagonizing the abnormal activation of the Wnt signaling pathway,suggesting that regulation of Wnt pathway signaling may become a potential MF therapeutic target. This article mainly on the Wnt signal pathway and myocardial fibrosis for a review,for the clinical treatment to provide a new direction.