文献类型：期刊文献

中文题名：非酒精性脂肪性肝病发病机制研究进展

英文题名：Research advances in pathogenesis of non-alcoholic fatty liver disease

作者：赵瀚东[1];杨帆[2];詹丽[2]

第一作者：赵瀚东

机构：[1]甘肃中医药大学第一临床医学院(甘肃省人民医院),甘肃兰州730000;[2]甘肃省人民医院消化科,甘肃兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2022

卷号：43

期号：3

起止页码：366

中文期刊名：解放军医学院学报

外文期刊名：Academic Journal of Chinese PLA Medical School

收录：CSTPCD;;北大核心:【北大核心2020】；

基金：甘肃省自然科学基金项目(21JR1RA032)。

语种：中文

中文关键词：非酒精性脂肪性肝病;病理学;自噬;遗传;氧化应激

外文关键词：non-alcoholic fatty liver disease;pathology;autophagy;genetic;oxidative stress

摘要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)已经成为我国最常见的慢性肝病,且发生率逐年增加。目前关于其具体发病机制尚不完全清楚,现被广泛认可的是基于“二次打击”学说提出的“多重打击”学说,该学说也为NAFLD的发病机制提供了更为准确的解释。本文结合近几年的相关研究,主要从胰岛素抵抗、自噬、肠道菌群、遗传因素、细胞外囊泡等方面对NAFLD的发病机制进行阐述,以期为NAFLD的临床治疗及研究提供相关参考。
Non-alcoholic fatty liver disease(NAFLD)has become the most common chronic liver disease in China,and its incidence is increasing year by year.At present,the specific pathogenesis is not clear,and the"multiple hit"theory based on the"second hit"theory is widely recognized,which also provides a more accurate explanation for the pathogenesis of NAFLD.Based on the related research in recent years,this article mainly discusses the pathogenesis of NAFLD from the aspects of insulin resistance,autophagy,intestinal flora,genetic factors,extracellular vesicles,etc,so as to provide relevant references for the clinical treatment and research of NAFLD.