文献类型：期刊文献

英文题名：The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer

作者：Liu, Songhua[1];Rong, Yao[1];Tang, Mingzheng[1];Zhao, Qiqi[2];Li, Chunyan[3];Gao, Wenbin[1];Yang, Xiaojun[3,4,5,6,7]

第一作者：刘树华;刘曙华

通信作者：Yang, XJ[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[2]Ningxia Med Univ, Coll Clin Med, Yinchuan 750004, Peoples R China;[3]Lanzhou Univ, Clin Med Sch 1, Lanzhou 730000, Peoples R China;[4]Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730000, Peoples R China;[5]Gansu Prov Hosp, Gansu Key Lab Mol Diagnost & Precis Med Surg Oncol, Lanzhou 730000, Peoples R China;[6]Gansu Prov Hosp, Gansu Res Ctr Prevent & Control Project Digest Onc, Lanzhou 730000, Peoples R China;[7]Natl Hlth & Hlth Commiss, Key Lab Gastrointestinal Tumor Diag & Treatment, 204 West Donggang Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Lanzhou Univ, Clin Med Sch 1, Lanzhou 730000, Peoples R China.

年份：2024

卷号：27

期号：18

起止页码：2639

外文期刊名：COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

收录：;Scopus(收录号：2-s2.0-85201699982);WOS:【SCI-EXPANDED(收录号:WOS:001320325800007)】；

基金：This work was supported by the Gansu Province innovation base and talent Project Funding (20JR10RA433); Key R & D Projects of the Provincial Science and Technology Program of Gansu Province (21YF5WA027); Scientific Research Program of Health Industry of Gansu Province (GSWSKY2020-45); National Health Care Commission Key Laboratory of Gastrointestinal Tumor Diagnosis and Treatment 2022 Master/Postdoctoral Fund Project (NHCDP2022001); Gansu Provincial Hospital Doctoral Supervision Incubation Program (22GSSYA-3); The Innovation Star Project of outstanding postgraduates from the Department of Education of Gansu Province (2022CXZX-746).

语种：英文

外文关键词：Gastric cancer; long non-coding RNA; small nucleolar RNA; host gene; biological function; molecular mechanisms

摘要：Gastric cancer (GC) is one of the most common malignancies worldwide. Despite significant advancements in surgical and adjuvant treatments, patient prognosis remains unsatisfactory. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that lack protein-coding capacity but can engage in the malignant biological behaviors of tumors through various mechanisms. Among them, small nucleolar host genes (SNHGs) represent a subgroup of lncRNAs. Studies have revealed their involvement not only in gastric cancer cell proliferation, invasion, migration, epithelial-mesenchymal transition (EMT), and apoptosis but also in chemotherapy resistance and tumor stemness. This review comprehensively summarizes the biological functions, molecular mechanisms, and clinical significance of SNHGs in gastric cancer. It provides novel insights into potential biomarkers and therapeutic targets for the exploration of gastric cancer.