文献类型：期刊文献

英文题名：Metal-Free Intramolecular [3+2] Cycloaddition of γ-Hydroxy Acetylenic Ketones with Alkynes for the Synthesis of Naphtho[1,2- c]furan-5-ones and Its Derivatization via a Selective C(sp2)-H Deuteration Reaction

作者：Ning, Si-Si[1]; Meng, Dan[1]; Zhang, Jie-Yun[1]; Liu, Shi-Lei[1]; Zhou, Ni-Ni[1]; Jin, Xiaojie[2]; Zhu, Hai-Tao[1]

第一作者：Ning, Si-Si

通信作者：Zhu, Hai-Tao

机构：[1] Shannxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, 721013, China; [2] Gansu Univ. Key Lab. for Molec. Med. and Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou, 730000, China

第一机构：Shannxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, 721013, China

通信机构：[1]Shannxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, 721013, China

年份：2021

卷号：86

期号：11

起止页码：7347

外文期刊名：Journal of Organic Chemistry

收录：EI(收录号：20212610557223);Scopus(收录号：2-s2.0-85108407078)

语种：英文

外文关键词：Organic pollutants - Aromatic compounds - Regioselectivity - Deuterium

摘要：A metal-free intramolecular [3+2] cycloaddtion has been achieved by treating benzene-linked propynol-ynes with AcOH/H2O in a one-pot manner. The reaction provides greener, 100% atom-economic, highly regioselective, and more practical access to functionalized naphtho[1,2-c]furan-5-ones with valuable and versatile applications. The regioselective α-deuteration of naphtho[1,2-c]furan-5-ones has been also presented with excellent deuterium incorporation and chemical yields. Moreover, the fluorescent properties of naphtho[1,2-c]furan-5-one products have been investigated in solution. ? 2021 American Chemical Society