文献类型：期刊文献

英文题名：Alterations of brain white matter network topological properties in overt hypothyroidism

作者：Tian, Jinghe[1];Zou, Quan[1];Cao, Jiancang[2];Wang, Liting[1];Tian, Jing[2];Yang, Chen[2];Ma, Wenxiu[1];Huang, Gang[2];Tan, Jian[1];Zhang, Wenwen[2];Zhao, Lianping[2]

第一作者：Tian, Jinghe

通信作者：Zhao, LP[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Radiol, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Radiol, Lanzhou, Gansu, Peoples R China.

年份：2025

卷号：14

期号：5

外文期刊名：ENDOCRINE CONNECTIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001551195800002)】；

基金：This work was supported by the Key Research and Development Program of Gansu Province, China (No. 23YFFA0048), the Guiding Plan Project for Scientific and Technological Development in Lanzhou City (No. 2019-ZD-97), the Gansu Traditional Chinese Medicine Management Scientific Research Project (No. GZKP-2020-36), the Foundation of Gansu Provincial Hospital (No. 24GSSYB-5), and the Outstanding Graduate Student Innovation Star Program (No. 2023CXZX-759).

语种：英文

外文关键词：overt hypothyroidism; white matter network; cognition; emotion

摘要：PurposeThis study examined the topological properties of brain white matter networks in overt hypothyroidism (OH) patients and their links to cognitive and emotional dysfunction.Materials and methodsFifty OH patients and 92 healthy controls underwent brain magnetic resonance imaging, clinical assessments and neuropsychological evaluations. Graph-theoretical network analysis based on diffusion tensor imaging was used to calculate global and local topological properties. Between-group differences were analyzed, and partial correlation and mediation analyses were conducted to explore relationships among topological metrics, clinical variables and neuropsychological scores.ResultsThe OH group showed significantly higher depressive and anxious scores, and lower cognitive scores. In the global topological analysis, the OH group showed decreased global efficiency, which was negatively correlated with the Hamilton Rating Scale for Depression-24 scores. Local topological abnormalities were predominantly observed in the nodal efficiency (NE), degree centrality and nodal local efficiency of several regions within the limbic system and default mode networks. Notably, NE in the left amygdala and left paracentral lobule was negatively correlated with the Hamilton Rating Scale for Depression-24 scores, and decreased NE in the right median cingulate and paracingulate gyri was positively correlated with executive function/visuospatial ability scores and the clock drawing test score.ConclusionOH patients show depression, anxiety and cognitive impairments linked to global efficiency and regional abnormalities in the limbic system and default mode network. These findings provide insights into the neuropathophysiological mechanisms underlying emotional and cognitive impairments.