文献类型：期刊文献

英文题名：Exploring the mechanism of TLR4/NF-κB signaling pathway in hypoxic myocardial injury: Implications for traditional Chinese medicine therapy

作者：Liang, Keke[1,2];Xu, Liang[1,2];Ta, Yanling[1,2];Wang, Renjie[1,2];Ma, Shuhe[1,2];Xiao, Chenrong[2];Zhang, Xianxie[2];Gao, Yue[2];Li, Maoxing[1,2]

第一作者：Liang, Keke

通信作者：Gao, Y[1];Li, MX[1]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Beijing Inst Radiat Med, Beijing 100850, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing, Peoples R China.

年份：2025

卷号：185

外文期刊名：FITOTERAPIA

收录：;Scopus(收录号：2-s2.0-105009596166);WOS:【SCI-EXPANDED(收录号:WOS:001527972200001)】；

基金：This study was supported by the Outstanding Doctoral Student Project of Gansu Province (Grant number: 25JRRA258) .

语种：英文

外文关键词：Hypoxic myocardial injury; TLR4/NF-kappa B signaling pathway; Traditional Chinese medicine (TCM) agents

摘要：Hypoxic myocardial injury is the core mechanism of many cardiovascular diseases and poses a serious threat to global public health. Its pathogenesis involves energy metabolism disorder, oxidative stress, inflammatory response, apoptosis regulation imbalance, and other links, resulting in myocardial dysfunction and damage. In recent years, a large number of studies have confirmed that the Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-kappa B) signaling network can regulate hypoxic myocardial injury by mediating HMGB1, MyD88, Caspase-3, HIF-1 alpha, TNF-alpha, NLRP3, HSP70, etc. Traditional Chinese Medicine (TCM) and its active components have obvious advantages in the treatment of complex diseases such as hypoxic myocardial injury, and inhibiting the key target of TLR4/NF-kappa B signaling network is one of the mechanisms of myocardial protection. However, there are few systematic reviews and summaries in this field. Based on this, this review summarizes the regulatory mechanism of TLR4/NF-kappa B signaling pathway involved in hypoxic myocardial injury and the intervention effect of TCM in recent years, to provide a theoretical basis for basic research and new drug development of hypoxic myocardial injury.